Establishment of Relative and Absolute Configurations of Phaeosphaeride A: Total Synthesis of ent-Phaeosphaeride A

被引：23

作者：

Kobayashi, Kenichi ^{[1
]}

Kobayashi, Yukiko ^{[1
]}

Nakamura, Misato ^{[1
]}

Tamura, Osamu ^{[2
]}

Kogen, Hiroshi ^{[1
]}

机构：

[1] Meiji Pharmaceut Univ, Grad Sch Pharmaceut Sci, Tokyo 2048588, Japan

[2] Showa Pharmaceut Univ, Machida, Tokyo 1948543, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 02期

关键词：

PROPOSED STRUCTURE; CANCER-THERAPY; STAT3;

D O I：

10.1021/jo5025046

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The relative and absolute configurations of phaeosphaeride A have been established via the first total synthesis of ent-phaeosphaeride A. The three contiguous stereogenic centers were installed by Sharpless asymmetric dihydroxylation and a stereoselective intramolecular vinyl anion aldol reaction. This synthesis has altered the originally proposed structure of natural phaeosphaeride A.

引用

页码：1243 / 1248

页数：6

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