Clinicopathological Features and Prognosis of Mucinous Cystic Neoplasm With Ovarian-Type Stroma A Multi-Institutional Study of the Japan Pancreas Society

被引：186

作者：

Yamao, Kenji ^{[1
]}

Yanagisawa, Akio ^{[2
]}

Takahashi, Kuniyuki ^{[3
]}

Kimura, Wataru ^{[4
]}

Doi, Ryuichiro ^{[5
]}

Fukushima, Noriyoshi ^{[6
]}

Ohike, Nobuyuki ^{[7
]}

Shimizu, Michio ^{[8
]}

Hatori, Takashi ^{[9
]}

Nobukawa, Bunsei ^{[10
]}

Hifumi, Michio ^{[11
]}

Kobayashi, Yuji ^{[12
]}

Tobita, Kosuke ^{[13
]}

Tanno, Satoshi ^{[14
]}

Sugiyama, Masanori ^{[15
]}

Miyasaka, Yoshihiro ^{[16
]}

Nakagohri, Toshio ^{[17
]}

Yamaguchi, Taketo ^{[18
]}

Hanada, Keiji ^{[19
]}

Abe, Hideki ^{[20
]}

Tada, Minoru ^{[21
]}

Fujita, Naotaka ^{[22
]}

Tanaka, Masao ^{[16
]}

机构：

[1] Aichi Canc Ctr Hosp, Dept Gastroenterol, Nagoya, Aichi 464, Japan

[2] Kyoto Prefectural Univ Med, Dept Pathol, Kyoto 602, Japan

[3] Teine Keijinkai Hosp, Ctr Gastroenterol, Sapporo, Hokkaido, Japan

[4] Yamagata Univ, Dept Surg Gastroenterol Gen Breast & Thyroid Surg, Yamagata 990, Japan

[5] Kyoto Univ, Dept Surg, Kyoto, Japan

[6] Jichi Med Univ, Dept Pathol, Shimotsuke, Tochigi, Japan

[7] Showa Univ, Dept Pathol, No Yokohama Hosp, Yokohama, Kanagawa, Japan

[8] Saitama Med Sch, Dept Pathol, Saitama, Japan

[9] Tokyo Womens Med Univ, Dept Surg, Inst Gastroenterol, Tokyo, Japan

[10] Juntendo Univ, Dept Human Pathol, Tokyo, Japan

[11] Japanese Red Cross Kumamoto Hosp, Dept Gastroenterol, Kumamoto, Japan

[12] Aichi Med Univ, Div Gastroenterol, Dept Internal Med, Aichi, Japan

[13] Tokai Univ, Dept Surg Gastroenterol, Isehara, Kanagawa, Japan

[14] Asahikawa Med Coll, Dept Gen Med, Asahikawa, Hokkaido 078, Japan

[15] Kyorin Univ, Sch Med, Dept Surg, Mitaka, Tokyo 181, Japan

[16] Kyushu Univ, Dept Surg & Oncol, Fukuoka 812, Japan

[17] Natl Canc Ctr Hosp E, Dept Surg, Kashiwa, Chiba, Japan

[18] Chiba Canc Ctr, Dept Gastroenterol, Chiba 2608717, Japan

[19] Onomichi Gen Hosp, Ctr Gastroendoscopy, Onomichi, Japan

[20] Ibaraki Prefectural Ctr Hosp, Dept Surg, Kasama, Ibaraki, Japan

[21] Univ Tokyo, Dept Gastroenterol, Tokyo, Japan

[22] Sendai City Med Ctr, Dept Gastroenterol, Sendai, Miyagi, Japan

来源：

PANCREAS | 2011年 / 40卷 / 01期

关键词：

mucinous cystic neoplasm; ovarian-type stroma; clinicopathological analysis; prognosis; TUMORS; CYSTADENOCARCINOMA; MALIGNANCY;

D O I：

10.1097/MPA.0b013e3181f749d3

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objective: The aim of this study was to elucidate the clinicopathological features and prognosis of mucinous cystic neoplasms (MCNs). Materials and Methods: We performed a multi-institutional, retrospective study on a collected series of patients with MCN pathologically defined by ovarian-type stroma. Clinicopathological features and prognosis were investigated. Result: Mucinous cystic neoplasm was confirmed in 156 cases, including 129 adenomas (82.7%) and 21 noninvasive (13.4%) and 6 invasive carcinomas (3.9%). Patients with MCN were exclusively women (98.1%) with the mean age of 48.1 years. All but 1 MCN were in the pancreatic body/tail region with a mean size of 65.3 mm. Communication between the cyst and the pancreatic duct was found in 18.1%. The 3-, 5-, and 10-year survival rates were 97.6%, 96.6%, and 96.6%, respectively. A significant difference in the survival rates was observed between adenomas and carcinomas and between minimally invasive carcinomas and invasive carcinomas. Cyst diameter and presence of mural nodule were predictive of malignant MCN. Conclusions: Mucinous cystic neoplasm is a rare but distinctive pancreatic cystic neoplasm with a favorable overall prognosis. All MCNs should be resected to prevent malignant changes but can be observed an appropriate time when the lesion is small without the presence of mural nodules.

引用

页码：67 / 71

页数：5

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