Estimating the economic burden of pneumococcal meningitis and pneumonia in northern Ghana in the African meningitis belt post-PCV13 introduction

被引:5
作者
Kobayashi, Miwako [1 ]
Abdul-Karim, Abass [2 ]
Milucky, Jennifer L. [1 ]
Zakariah, Adam [3 ]
Leidner, Andrew J. [4 ]
Asiedu-Bekoe, Franklin [5 ]
Opare, David [5 ]
Eleeza, John B. [6 ]
Ofosu, Winfred [7 ]
Walker, Chastity [8 ]
Whitney, Cynthia G. [9 ]
Lessa, Fernanda C. [1 ]
机构
[1] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Bacterial Dis, Atlanta, GA USA
[2] Zonal Publ Hlth Lab, Tamale, Ghana
[3] Ghana Hlth Serv, Bulisa, Ghana
[4] Natl Ctr Immunizat & Resp Dis, Ctr Dis Control & Prevent, Immunizat Serv Div, Atlanta, GA USA
[5] Ghana Hlth Serv, Accra, Ghana
[6] Ghana Hlth Serv, Tamale, Ghana
[7] Ghana Hlth Serv, Bolgatanga, Ghana
[8] Ctr Global Hlth, Div Global Hlth Protect, Accra, Ghana
[9] Emory Univ, Rollins Sch Publ Hlth, Dept Global Hlth, Atlanta, GA USA
关键词
13-valent pneumococcal conjugate vaccine; African meningitis belt; Economic burden of pneumococcal disease; BACTERIAL-MENINGITIS; CONJUGATE VACCINE; STREPTOCOCCUS-PNEUMONIAE; MENINGOCOCCAL SEROGROUP; BURKINA-FASO; DISEASE; COUNTRIES; OUTBREAK; CHILDREN; SEQUELAE;
D O I
10.1016/j.vaccine.2021.06.043
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background: Ghana introduced 13-valent pneumococcal conjugate vaccine (PCV13) into the routine infant immunization program in 2012, using a three-dose primary series without a booster. Despite 5 years), $911 (5-14 years), and $784 ( 5 years), $3,247 (5-14 years), and $2,883 ( 15 years). Most (78.0-93.4%) of the total societal cost was due to indirect costs related to deaths from PCV13-type diseases. Conclusions: The estimated economic burden of PCV13-type disease in northern Ghana remains substantial, especially in older children and adults who were expected to have benefited from indirect effects from infant immunization. Additional interventions such as changes in the infant immunization schedule, reactive vaccination, or catch-up PCV13 vaccination may be needed to control remaining vaccine type disease. Published by Elsevier Ltd.
引用
收藏
页码:4685 / 4699
页数:15
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