Facile syntheses of functionalized toll-like receptor 7 agonists

被引：5
|
作者：
Akinbobuyi, Babatope [1 ]
Byrd, Matthew R. [1 ]
Chang, Charles A. [2 ]
Nguyen, Mysa [1 ]
Seifert, Zacharie J. [1 ]
Flamar, Anne-Laure [3 ]
Zurawski, Gerard [2 ,3 ]
Upchurch, Katherine C. [2 ]
Oh, SangKon [2 ,3 ]
Dempsey, Stephen H. [4 ]
Enke, Thomas J. [4 ]
Le, John [4 ]
Winstead, Hunter J. [4 ]
Boquin, Jose R. [4 ]
Kane, Robert R. [1 ,2 ,3 ]
机构：
[1] Baylor Univ, Dept Chem & Biochem, Waco, TX 76798 USA
[2] Baylor Univ, Inst Biomed Studies, Waco, TX 76798 USA
[3] Baylor Res Inst, Baylor Inst Immunol Res, Dallas, TX 75204 USA
[4] Augustana Coll, Dept Chem, Rock Isl, IL 61201 USA
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 02期
关键词：
Toll-like receptor; Adenine derivatives; Vaccines; Immune activation; POTENT INTERFERON-INDUCERS; 8-OXOADENINE DERIVATIVES; BIOLOGICAL EVALUATION; INNATE IMMUNITY; IMIDAZOQUINOLINES; 8-HYDROXYADENINES; 9-BENZYLADENINES; RECOGNITION; DISCOVERY; VACCINES;
D O I：
10.1016/j.tetlet.2014.11.126
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Protein conjugates of toll-like receptor 7 agonists have been shown to elicit powerful immune responses. In order to facilitate our studies in this area our group has developed efficient syntheses for a number of functionalized derivatives that retain immune stimulatory activity. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：458 / 460
页数：3
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