Facile syntheses of functionalized toll-like receptor 7 agonists

被引：5

作者：

Akinbobuyi, Babatope ^{[1
]}

Byrd, Matthew R. ^{[1
]}

Chang, Charles A. ^{[2
]}

Nguyen, Mysa ^{[1
]}

Seifert, Zacharie J. ^{[1
]}

Flamar, Anne-Laure ^{[3
]}

Zurawski, Gerard ^{[2
,3
]}

Upchurch, Katherine C. ^{[2
]}

Oh, SangKon ^{[2
,3
]}

Dempsey, Stephen H. ^{[4
]}

Enke, Thomas J. ^{[4
]}

Le, John ^{[4
]}

Winstead, Hunter J. ^{[4
]}

Boquin, Jose R. ^{[4
]}

Kane, Robert R. ^{[1
,2
,3
]}

机构：

[1] Baylor Univ, Dept Chem & Biochem, Waco, TX 76798 USA

[2] Baylor Univ, Inst Biomed Studies, Waco, TX 76798 USA

[3] Baylor Res Inst, Baylor Inst Immunol Res, Dallas, TX 75204 USA

[4] Augustana Coll, Dept Chem, Rock Isl, IL 61201 USA

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 02期

关键词：

Toll-like receptor; Adenine derivatives; Vaccines; Immune activation; POTENT INTERFERON-INDUCERS; 8-OXOADENINE DERIVATIVES; BIOLOGICAL EVALUATION; INNATE IMMUNITY; IMIDAZOQUINOLINES; 8-HYDROXYADENINES; 9-BENZYLADENINES; RECOGNITION; DISCOVERY; VACCINES;

D O I：

10.1016/j.tetlet.2014.11.126

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Protein conjugates of toll-like receptor 7 agonists have been shown to elicit powerful immune responses. In order to facilitate our studies in this area our group has developed efficient syntheses for a number of functionalized derivatives that retain immune stimulatory activity. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：458 / 460

页数：3

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