Facile syntheses of functionalized toll-like receptor 7 agonists

被引：5
|
作者：
Akinbobuyi, Babatope [1 ]
Byrd, Matthew R. [1 ]
Chang, Charles A. [2 ]
Nguyen, Mysa [1 ]
Seifert, Zacharie J. [1 ]
Flamar, Anne-Laure [3 ]
Zurawski, Gerard [2 ,3 ]
Upchurch, Katherine C. [2 ]
Oh, SangKon [2 ,3 ]
Dempsey, Stephen H. [4 ]
Enke, Thomas J. [4 ]
Le, John [4 ]
Winstead, Hunter J. [4 ]
Boquin, Jose R. [4 ]
Kane, Robert R. [1 ,2 ,3 ]
机构：
[1] Baylor Univ, Dept Chem & Biochem, Waco, TX 76798 USA
[2] Baylor Univ, Inst Biomed Studies, Waco, TX 76798 USA
[3] Baylor Res Inst, Baylor Inst Immunol Res, Dallas, TX 75204 USA
[4] Augustana Coll, Dept Chem, Rock Isl, IL 61201 USA
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 02期
关键词：
Toll-like receptor; Adenine derivatives; Vaccines; Immune activation; POTENT INTERFERON-INDUCERS; 8-OXOADENINE DERIVATIVES; BIOLOGICAL EVALUATION; INNATE IMMUNITY; IMIDAZOQUINOLINES; 8-HYDROXYADENINES; 9-BENZYLADENINES; RECOGNITION; DISCOVERY; VACCINES;
D O I：
10.1016/j.tetlet.2014.11.126
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Protein conjugates of toll-like receptor 7 agonists have been shown to elicit powerful immune responses. In order to facilitate our studies in this area our group has developed efficient syntheses for a number of functionalized derivatives that retain immune stimulatory activity. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：458 / 460
页数：3
相关论文
共 50 条
  • [1] Toll-like receptor 4, Toll-like receptor 7 and Toll-like receptor 9 agonists enhance immune responses against blood-stage Plasmodium chabaudi infection in BALB/c mice
    Gao, Wenyan
    Sun, Xiaodan
    Li, Danni
    Sun, Lin
    He, Yang
    Wei, Huanping
    Jin, Feng
    Cao, Yaming
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2020, 89
  • [2] The use of Toll-like receptor 7/8 agonists as vaccine adjuvants
    Vasilakos, John P.
    Tomai, Mark A.
    EXPERT REVIEW OF VACCINES, 2013, 12 (07) : 809 - 819
  • [3] Syntheses of fluorescent imidazoquinoline conjugates as probes of Toll-like receptor 7
    Shukla, Nikunj M.
    Mutz, Cole A.
    Ukani, Rehman
    Warshakoon, Hemamali J.
    Moore, David S.
    David, Sunil A.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (22) : 6384 - 6386
  • [4] Toll-Like Receptor 9 Agonists in Cancer
    Karapetyan, Lilit
    Luke, Jason J.
    Davar, Diwakar
    ONCOTARGETS AND THERAPY, 2020, 13 : 10039 - 10060
  • [5] Design and synthesis of tetrahydropyridopyrimidine based Toll-Like Receptor (TLR) 7/8 dual agonists
    McGowan, David C.
    Herschke, Florence
    Khamlichi, Mourad D.
    Luz Rosauro, Mari
    Perez Benedicto, Sara M.
    Pauwels, Frederik
    Stoops, Bart
    Pande, Vineet
    Scholliers, Annick
    Van Schoubroeck, Bertrand
    Mostmans, Wendy
    Van Dijck, Kris
    Thone, Tine
    Horton, Helen
    Fanning, Gregory
    Jonckers, Tim H. M.
    Raboisson, Pierre
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (19) : 3216 - 3221
  • [6] Toll-like receptor 7 and Toll-like receptor 9 agonists effectively enhance immunological memory in Plasmodium chabaudi infected BALB/c mice
    Gao, Wenyan
    Sun, Xiaodan
    Li, Danni
    Sun, Lin
    He, Yang
    Wei, Huanping
    Jin, Feng
    Cao, Yaming
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2020, 81
  • [7] Toll-like receptor agonists in cancer therapy
    Adams, Sylvia
    IMMUNOTHERAPY, 2009, 1 (06) : 949 - 964
  • [8] Discovery of selective 2,4-diaminoquinazoline toll-like receptor 7 (TLR 7) agonists
    Pieters, Serge
    McGowan, David
    Herschke, Florence
    Pauwels, Frederik
    Stoops, Bart
    Last, Stefaan
    Embrechts, Werner
    Scholliers, Annick
    Mostmans, Wendy
    Van Dijck, Kris
    Van Schoubroeck, Bertrand
    Thone, Tine
    De Pooter, Dorien
    Fanning, Gregory
    Luz Rosauro, Mari
    Daoubi Khamlichi, Mourad
    Houpis, Ioannis
    Arnoult, Eric
    Jonckers, Tim H. M.
    Raboisson, Pierre
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (04) : 711 - 719
  • [9] Antiviral applications of Toll-like receptor agonists
    Horscroft, Nigel J.
    Pryde, David C.
    Bright, Helen
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2012, 67 (04) : 789 - 801
  • [10] Synthesis and immunoregulatory activities of conjugates of a Toll-like receptor 7 inert ligand
    Gao, Dong
    Liu, Yu
    Li, Wang
    Zhong, Fangshu
    Zhang, Xiaoli
    Diao, Yuwen
    Gao, Ningning
    Wang, Xiaodong
    Jiang, Wenqi
    Jin, Guangyi
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (24) : 5792 - 5795
12345