Identification of two novel prenylated flavonoids in mulberry leaf and their bioactivities

被引：56

作者：

Wen, Lingrong ^{[1
,2
,4
]}

Shi, Dingding ^{[1
,4
]}

Zhou, Ting ^{[1
,4
]}

Tu, Jiaming ^{[1
,4
]}

He, Mingyang ^{[1
,3
]}

Jiang, Yueming ^{[1
,2
,4
]}

Yang, Bao ^{[1
,2
,4
]}

机构：

[1] Chinese Acad Sci, South China Bot Garden, Key Lab Plant Resource Conservat & Sustainable Ut, Key Lab Postharvest Handling Fruits,Minist Agr, Guangzhou 510650, Peoples R China

[2] Chinese Acad Sci, Core Bot Gardens, Guangzhou 510650, Peoples R China

[3] Southwest Univ, Chinese Acad Agr Sci, Citrus Res Inst, Chongqing 400712, Peoples R China

[4] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

FOOD CHEMISTRY | 2020年 / 315卷

基金：

中国国家自然科学基金;

关键词：

Prenylated flavonoid; Morus alba; Antioxidant activity; Bioactivity; NMR; OXIDATIVE STRESS; CELL-DEATH; IRON; ANTIOXIDANT; FERROPTOSIS; LITCHI;

D O I：

10.1016/j.foodchem.2020.126236

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Mulberry leaf is a vegetable used in daily diet. It can bring delicious taste and multiple health benefits. However, the chemicals responsible for these health benefits remain unveiled. In this work, two novel prenylated flavonoids were isolated from mulberry leaf. Their structures were identified and named as morachalcone D and morachalcone E. The protective effects of these two compounds were investigated, against endogenous oxidative damage (oxytosis/ferroptosis) induced by glutamate and erastin in HT22 cells. The results revealed that morachalcone D was much more potent in preventing from glutamate- and erastin-induced cell death than morachalcone E. The neuroprotective effect of morachalcone D was related to the prevention of ROS production, glutathione depletion, and iron accumulation. Morachalcone D upregulated the expression of genes involved in antioxidant defense, including GPx4, CAT, SOD2, Nrf2, HMOX1 and SLC7A11. These findings indicated that morachalcone D was responsible for the health benefits of mulberry leaf, and could be a potent neuroprotective agent for use in dietary supplements and functional foods.

引用

页数：11

共 43 条

[1] Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration [J].

Abdalkader, Moataz ;

Lampinen, Riikka ;

Kanninen, Katja M. ;

Malm, Tarja M. ;

Liddell, Jeffrey R. .

FRONTIERS IN NEUROSCIENCE, 2018, 12

[2] Mitochondrial Biology and Neurological Diseases [J].

Arun, Siddharth ;

Liu, Lei ;

Donmez, Gizem .

CURRENT NEUROPHARMACOLOGY, 2016, 14 (02) :143-154

[3] Heme oxygenase-1 mediates BAY 11-7085 induced ferroptosis [J].

Chang, Ling-Chu ;

Chiang, Shih-Kai ;

Chen, Shuen-Ei ;

Yu, Yung-Luen ;

Chou, Ruey-Hwang ;

Chang, Wei-Chao .

CANCER LETTERS, 2018, 416 :124-137

[4] Metabolomic analysis of energy regulated germination and sprouting of organic mung bean (Vigna radiata) using NMR spectroscopy [J].

Chen, Lin ;

Wu, Ji'en ;

Li, Zhanming ;

Liu, Qin ;

Zhao, Xue ;

Yang, Hongshun .

FOOD CHEMISTRY, 2019, 286 :87-97

[5] Dietary Total Prenylflavonoids from the Fruits of Psoralea corylifolia L. Prevents Age-Related Cognitive Deficits and Down-Regulates Alzheimer's Markers in SAMP8 Mice [J].

Chen, Zhi-Jing ;

Yang, Yan-Fang ;

Zhang, Ying-Tao ;

Yang, Dong-Hui .

MOLECULES, 2018, 23 (01)

[6] Antioxidant and iron-binding properties of curcumin, capsaicin, and S-Allylcysteine reduce oxidative stress in rat brain homogenate [J].

Dairam, Amichand ;

Fogel, Ronen ;

Daya, Santy ;

Limson, Janice L. .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2008, 56 (09) :3350-3356

[7] Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage [J].

DeGregorio-Rocasolano, Nuria ;

Marti-Sistac, Octavi ;

Ponce, Jovita ;

Castello-Ruiz, Maria ;

Millan, Monica ;

Guirao, Veronica ;

Garcia-Yebenes, Isaac ;

Salom, Juan B. ;

Ramos-Cabrer, Pedro ;

Alborch, Enrique ;

Lizasoain, Ignacio ;

Castillo, Jose ;

Davalos, Antoni ;

Gasull, Teresa .

REDOX BIOLOGY, 2018, 15 :143-158

[8] Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis [J].

Dixon, Scott J. ;

Patel, Darpan ;

Welsch, Matthew ;

Skouta, Rachid ;

Lee, Eric ;

Hayano, Miki ;

Thomas, Ajit G. ;

Gleason, Caroline ;

Tatonetti, Nicholas ;

Slusher, Barbara S. ;

Stockwell, Brent R. .

ELIFE, 2014, 3

[9] Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death [J].

Dixon, Scott J. ;

Lemberg, Kathryn M. ;

Lamprecht, Michael R. ;

Skouta, Rachid ;

Zaitsev, Eleina M. ;

Gleason, Caroline E. ;

Patel, Darpan N. ;

Bauer, Andras J. ;

Cantley, Alexandra M. ;

Yang, Wan Seok ;

Morrison, Barclay, III ;

Stockwell, Brent R. .

CELL, 2012, 149 (05) :1060-1072

[10] Neuroprotective strategies involving ROS in Alzheimer disease [J].

Dumont, Magali ;

Beal, M. Flint .

FREE RADICAL BIOLOGY AND MEDICINE, 2011, 51 (05) :1014-1026

← 1 2 3 4 5 →