WHO classification of soft tissue tumours 2020: An update and simplified approach for radiologists

被引:58
作者
Bansal, Abhinav [1 ]
Goyal, Surbhi [2 ]
Goyal, Ankur [1 ]
Jana, Manisha [1 ]
机构
[1] All India Inst Med Sci, Dept Radiodiag & Intervent Radiol, Room 82, New Delhi 110029, India
[2] GB Pant Inst, Dept Pathol, Post Grad Med Educ & Res, New Delhi, India
关键词
Musculoskeletal; Soft tissue tumours; WHO classification; Pathology; Imaging; LARGE REFERRAL POPULATION; IMAGING FEATURES; NEAR-HAPLOIDIZATION; MRI FEATURES; GENE FUSIONS; SARCOMAS; DIFFERENTIATION; LIPOSARCOMA; MUTATIONS; DIAGNOSES;
D O I
10.1016/j.ejrad.2021.109937
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The WHO classification of soft tissue tumours categorizes the lesions based on histological differentiation. In the recent fifth edition (2020), many new entities have been introduced, based on their distinct biological behaviour, genetics and morphology. With the recent advances and better understanding of molecular genetics, several novel recurrent genetic alterations have been incorporated in this edition. These may serve as reliable diagnostic and prognostic markers for various soft tissue tumours. Though predominantly a pathologist's game; the radiologists must be aware of the recent updates to contribute towards the optimal diagnosis and management of soft tissue tumours. The imaging features of the new entities have not yet been described but are expected to be explored in the coming years. We hereby present a concise review of the updates in the recent WHO classification of soft tissue tumours. We have tried to emphasize the novel molecular genetics and their surrogate immunohistochemical markers which have brought a paradigm shift in the diagnosis, therapeutics, and prognosis of soft tissue tumours. We also present simplified diagnostic algorithms to characterize soft tissue tumours based on the clinico-radiological features.
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页数:17
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