Relationship of APOE, age at onset, amyloid and clinical phenotype in Alzheimer disease

被引:15
作者
Whitwell, Jennifer L. [1 ]
Tosakulwong, Nirubol [2 ]
Weigand, Stephen D. [2 ]
Graff-Radford, Jonathan [3 ]
Ertekin-Taner, Nilufer [4 ]
Machulda, Mary M. [5 ]
Duffy, Joseph R. [3 ]
Schwarz, Christopher G. [1 ]
Senjem, Matthew L. [1 ,6 ]
Jack, Clifford R. [1 ]
Lowe, Val J. [1 ]
Josephs, Keith A. [3 ]
机构
[1] Mayo Clin, Dept Radiol, 200 1st St SW, Rochester, MN 55905 USA
[2] Mayo Clin, Dept Quantitat Hlth Sci, Rochester, MN USA
[3] Mayo Clin, Dept Neurol, Rochester, MN USA
[4] Mayo Clin, Dept Neurosci, Jacksonville, FL USA
[5] Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA
[6] Mayo Clin, Dept Informat Technol, Rochester, MN USA
基金
美国国家卫生研究院;
关键词
Apolipoprotein; Atypical Alzheimer's disease; Posterior cortical atrophy; Logopenic; Beta-amyloid; PET; APOLIPOPROTEIN-E EPSILON-4; CEREBROSPINAL-FLUID LEVELS; TYPE-4; ALLELE; BETA PEPTIDE; E GENOTYPE; ASSOCIATION; LOAD; VARIANTS; DEMENTIA; BINDING;
D O I
10.1016/j.neurobiolaging.2021.08.012
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
The apolipoprotein E (APOE) epsilon 4 allele is the most well-established risk factor for Alzheimer's disease (AD), although its relationship to age at onset and clinical phenotype is unclear. We aimed to assess relationships between APOE genotype and age at onset, amyloid-beta (A beta) deposition and typical versus atypical clinical presentations in AD. Frequency of APOE epsilon 4 carriers by age at onset was assessed in 447 AD patients, 138 atypical AD patients recruited by the Neurodegenerative Research Group at Mayo Clinic, and 309 with typical AD from ADNI. APOE epsilon 4 frequency increased with age at onset in atypical AD but showed a bell-shaped curve in typical AD where highest frequencies were observed between 65 and 70 years. Typical AD showed higher APOE epsilon 4 frequencies than atypical AD only between the ages of 57 and 69 years. Global A beta standard uptake value ratios did not differ according to APOE e4 status in either group. APOE genotype varies by both age at onset and clinical phenotype in AD, highlighting the heterogeneous nature of AD. (C) 2021 Elsevier Inc. All rights reserved.
引用
收藏
页码:90 / 98
页数:9
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