Small molecular floribundiquinone B derived from medicinal plants inhibits acetylcholinesterase activity

被引：24

作者：

Niu, Bing ^{[1
,3
]}

Zhang, Mengying ^{[1
]}

Du, Pu ^{[4
]}

Jiang, Li ^{[1
]}

Qin, Rui ^{[6
]}

Su, Qiang ^{[1
]}

Chen, Fuxue ^{[1
]}

Du, Dongshu ^{[1
,7
]}

Shu, Yilai ^{[5
]}

Chou, Kuo-Chen ^{[2
,3
]}

机构：

[1] Shanghai Univ, Coll Life Sci, Shanghai Key Lab Bioenergy Crops, Shanghai 200444, Peoples R China

[2] Univ Elect Sci & Technol China, Ctr Informat Biol, Chengdu 610054, Sichuan, Peoples R China

[3] Gordon Life Sci Inst, Boston, MA 02478 USA

[4] First Peoples Hosp Foshan, Dept Neurol, Foshan 528000, Peoples R China

[5] Fudan Univ, Shanghai Med Coll, Dept Otolaryngol Head & Neck Surg, Eye & Ear,Nose,Throat, Shanghai 200031, Peoples R China

[6] Guangxi Med Univ, Minzu Hosp Guangxi Zhuang Autonomous Reg, Affiliated Minzu Hosp, Dept Gynecol, Nanning 530001, Peoples R China

[7] Heze Univ, Dept Life Sci, Heze 274500, Shandong, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 34期

基金：

中国国家自然科学基金;

关键词：

Alzheimer's disease (AD); floribundiquinone B (FB); plant inhibitor; acetylcholinesterase (AChE); fluorescence quenching; M2 PROTON CHANNEL; RECOGNITION SEQUENCE PEPTIDES; FREQUENCY VIBRATIONS PHONONS; HUMAN-SERUM-ALBUMIN; TERTIARY STRUCTURE; ALZHEIMERS-DISEASE; CHOLINESTERASE-INHIBITORS; BIOLOGICAL FUNCTIONS; FLUORESCENCE SPECTROSCOPY; COLLECTIVE MOTION;

D O I：

10.18632/oncotarget.19169

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Being a neurodegenerative disorder, Alzheimer's disease (AD) is the one of the most terrible diseases. And acetylcholinesterase (AChE) is considered as an important target for treating AD. Acetylcholinesterase inhibitors (AChEI) are considered to be one of the effective drugs for the treatment of AD. The aim of this study is to find a novel potential AChEI as a drug for the treatment of AD. In this study, instead of using the synthetic compounds, we used those extracted from plants to investigate the interaction between floribundiquinone B (FB) and AChE by means of both the experimental approach such as fluorescence spectra, ultraviolet-visible (UV-vis) absorption spectrometry, circular dichroism (CD) and the theoretical approaches such as molecular docking. The findings reported here have provided many useful clues and hints for designing more effective and less toxic drugs against Alzheimer's disease.

引用

页码：57149 / 57162

页数：14

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