Asymmetric multicomponent reactions (AMCRs):: The new frontier

被引：1743

作者：

Ramón, DJ

Yus, M

机构：

[1] Univ Alicante, Inst Sintesis Organ, Fac Ciencias, E-03080 Alicante, Spain

[2] Univ Alicante, Dept Quim Organ, Fac Ciencias, E-03080 Alicante, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 11期

关键词：

asymmetric synthesis; C-C coupling; multicomponent reactions; synthetic methods;

D O I：

10.1002/anie.200460548

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Asymmetric multicomponent reactions involve the preparation of chiral compounds by the reaction of three or more reagents added simultaneously. This kind of addition and reaction has some advantages over classic divergent reaction strategies, such as lower costs, time, and energy, as well as environmentally friendlier aspects. All these advantages, together with the high level of stereoselectivity attained in some of these reactions, will force chemists in industry as in academia to adopt this new strategy of synthesis, or at least to consider it as a viable option. The positive aspects as well as the drawbacks of this strategy are discussed in this Review. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1602 / 1634

页数：33

共 507 条

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