Iron deficiency in obese postmenopausal women

被引:107
作者
Lecube, Albert
Carrera, Alicia
Losada, Eladio
Hernandez, Cristina
Simo, Rafael
Mesa, Jordi
机构
[1] Hosp Gen Valle Hebron, Div Endocrinol, Obes Res Unit, Barcelona 08035, Spain
[2] Hosp Gen Valle Hebron, Dept Hematol, Barcelona, Spain
[3] Hosp Gen Valle Hebron, Diabet Res Unit, Div Endocrinol, Barcelona, Spain
关键词
iron status; adult; soluble transferrin receptor; women; anemia;
D O I
10.1038/oby.2006.198
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: This study evaluates whether the iron deficiency suggested in children and adolescents with overweight is also present with increasing age. Research Methods and Procedures: We examined 50 consecutive postmenopausal nondiabetic white women with a BMI >= 30 kg/m(2) and 50 non-obese seemingly healthy women as a control group. In addition to the traditional indices of iron status, we measured the soluble transferrin receptor (sTfR) levels, a sensitive and highly quantitative indicator of early iron deficiency not influenced by the acute phase response. Results: Obese women have higher serum sTfR levels than control subjects [1.38 (range, 0.89 to 2.39) vs. 1.16 mg/dL (range, 0.69 to 2.03 mg/dL); p < 0.001]. However, no difference in ferritin concentration was observed between the groups [70.50 (range, 18 to 219) vs. 69.50 ng/mL (range, 24 to 270 ng/mL); p = not significant]. A positive correlation between BMI and sTfR concentration was detected. On multiple regression analyses, BMI (positively) and ferritin (inversely) were independent predictors accounting for sTfR. Discussion: These results suggest that a moderate degree of iron deficiency is also present among adult women with obesity. The determination of sTfR is. useful in the evaluation of iron status in this condition. Further studies with a greater number of patients are required to investigate the relationship between tissue iron concentrations and obesity.
引用
收藏
页码:1724 / 1730
页数:7
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