Array-based sensing of proteins using conjugated polymers

被引：239
|
作者：
Miranda, Oscar R.
You, Chang-Cheng
Phillips, Ronnie
Kim, Ik-Bum
Ghosh, Partha S.
Bunz, Uwe H. F.
Rotello, Vincent M.
机构：
[1] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA
[2] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 32期
关键词：
D O I：
10.1021/ja0737927
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A sensor array comprising six functionalized poly(p-phenyleneethynylene) polymers was constructed and used to detect and identify protein analytes. The presence of proteins alters the fluorescence properties of the polymers, generating a distinct fluorescence response pattern for a given protein. Linear discriminant analyses accurately differentiate the patterns of 17 proteins at nano- to micromolar concentrations. An identification accuracy of 97% was obtained on the basis of the tests with 68 unknown protein samples from the training set.
引用
收藏
页码：9856 / +
页数：3
相关论文
共 50 条
  • [21] Array-based vapor sensing using chemically sensitive carbon black polymer resistors.
    Severin, EJ
    Doleman, BJ
    Sanner, RD
    Lonergan, MC
    Grubbs, RH
    Lewis, NS
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1997, 213 : 35 - BTEC
  • [22] Array-Based Sensing of Metastatic Cells and Tissues Using Nanoparticle-Fluorescent Protein Conjugates
    Rana, Subinoy
    Singla, Arvind K.
    Bajaj, Avinash
    Elci, S. Gokhan
    Miranda, Oscar R.
    Mout, Rubui
    Yan, Bo
    Jirik, Frank R.
    Rotello, Vincent M.
    ACS NANO, 2012, 6 (09) : 8233 - 8240
  • [23] Array-based pyrosequencing
    Gharizadeh, Baback
    Goel, Sanket
    Eltoukhy, Helmy
    Agah, Mohsen Nemat -Corgani Ali
    Babrzadeh, Farbod
    Jalili, Roxana
    Talasaz, Amir -Ali H.
    Davis, Ronald W.
    Ronaghi, Mostafa
    PROGRESS ON POST-GENOME TECHNOLOGIES, 2007, : 8 - 9
  • [24] Array-based microbial identification upon extracellular aminoglycoside residue sensing
    Xizhe Li
    Bingyu Li
    Ruirui Liu
    Yanhua Dong
    Yayan Wu
    Analytical and Bioanalytical Chemistry, 2021, 413 : 4689 - 4696
  • [25] Array-based microbial identification upon extracellular aminoglycoside residue sensing
    Li, Xizhe
    Li, Bingyu
    Liu, Ruirui
    Dong, Yanhua
    Wu, Yayan
    ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2021, 413 (18) : 4689 - 4696
  • [26] Array-based microbial identification upon extracellular aminoglycoside residue sensing
    Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Analytical Chemistry and Instrument for Life Science, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an
    Shaanxi
    710049, China
    不详
    WA
    6009, Australia
    Anal. Bioanal. Chem., 2021, 18 (4689-4696):
  • [27] Array-based identification of genes and proteins associated with resistance to EGFR inhibitors
    Benavente, Sergio
    Armstrong, Eric
    Hsu, Kun-Tai
    Huang, Shyhmin
    Harari, Paul M.
    CANCER RESEARCH, 2006, 66 (08)
  • [28] Electrochemical multianalyte immunoassays using an array-based sensor
    Wilson, MS
    Nie, WY
    ANALYTICAL CHEMISTRY, 2006, 78 (08) : 2507 - 2513
  • [29] Combustion monitoring using infrared array-based detectors
    Carter, CF
    Cross, N
    MEASUREMENT SCIENCE AND TECHNOLOGY, 2003, 14 (07) : 1117 - 1122
  • [30] Multifunctional flexible sensor array-based damage monitoring for switch rail using passive and active sensing
    Hu, Pan
    Wang, Haitao
    Tian, Guiyun
    Liu, Yang
    Li, Xin
    Spencer, Billie F.
    SMART MATERIALS AND STRUCTURES, 2020, 29 (09)
12345