Array-based sensing of proteins using conjugated polymers

被引：239
|
作者：
Miranda, Oscar R.
You, Chang-Cheng
Phillips, Ronnie
Kim, Ik-Bum
Ghosh, Partha S.
Bunz, Uwe H. F.
Rotello, Vincent M.
机构：
[1] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA
[2] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 32期
关键词：
D O I：
10.1021/ja0737927
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A sensor array comprising six functionalized poly(p-phenyleneethynylene) polymers was constructed and used to detect and identify protein analytes. The presence of proteins alters the fluorescence properties of the polymers, generating a distinct fluorescence response pattern for a given protein. Linear discriminant analyses accurately differentiate the patterns of 17 proteins at nano- to micromolar concentrations. An identification accuracy of 97% was obtained on the basis of the tests with 68 unknown protein samples from the training set.
引用
收藏
页码：9856 / +
页数：3
相关论文
共 50 条
  • [1] Array-Based Sensing of Normal, Cancerous, and Metastatic Cells Using Conjugated Fluorescent Polymers
    Bajaj, Avinash
    Miranda, Oscar R.
    Phillips, Ronnie
    Kim, Ik-Bum
    Jerry, D. Joseph
    Bunz, Uwe H. F.
    Rotello, Vincent M.
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (03) : 1018 - 1022
  • [2] Fluorescence array-based sensing of nitroaromatics using conjugated polyelectrolytes
    Wu, Jiatao
    Tan, Chunyan
    Chen, Zhifang
    Chen, Yu Zong
    Tan, Ying
    Jiang, Yuyang
    ANALYST, 2016, 141 (11) : 3242 - 3245
  • [3] Fluorescence Array-Based Sensing of Metal Ions Using Conjugated Polyelectrolytes
    Wu, Yi
    Tan, Ying
    Wu, Jiatao
    Chen, Shangying
    Chen, Yu Zong
    Zhou, Xinwen
    Jiang, Yuyang
    Tan, Chunyan
    ACS APPLIED MATERIALS & INTERFACES, 2015, 7 (12) : 6882 - 6888
  • [4] Polyelectrolyte Complexes Formed from Conjugated Polymers: Array-Based Sensing of Organic Acids
    Han, Jinsong
    Bender, Markus
    Hahn, Sebastian
    Seehafer, Kai
    Bunz, Uwe H. F.
    CHEMISTRY-A EUROPEAN JOURNAL, 2016, 22 (10) : 3230 - 3233
  • [5] Array-based sensing using gold nanoparticle and fluorescent proteins for cancer diagnostics
    Geng, Yingying
    Yoshii, Tatsuyushi
    Ngoc Le
    Goel, Hira
    Zheng, Feng
    Mercurio, Arthur
    Rotello, Vincent
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252
  • [6] Array-Based Sensing of Proteins and Bacteria By Using Multiple Luminescent Nanodots as Fluorescent Probes
    Tao, Yu
    Ran, Xiang
    Ren, Jinsong
    Qu, Xiaogang
    SMALL, 2014, 10 (18) : 3667 - 3671
  • [7] Multistep Array-Based Sensing of Bioanalytes Using Modified MoS2, Fluorescence Proteins, and Cucurbituril
    Behera, Pradipta
    Baidya, Sourav
    Sahoo, Jagabandhu
    Jaiswal, Komal
    Singh, Devendra Pratap
    Pradhan, Soumen
    Saini, Deepak Kumar
    Agasti, Sarit S.
    De, Mrinmoy
    ACS APPLIED BIO MATERIALS, 2024, 7 (10): : 6371 - 6381
  • [8] Array-based sensing using nanoparticles: an alternative approach for cancer diagnostics
    Le, Ngoc D. B.
    Yazdani, Mahdieh
    Rotello, Vincent M.
    NANOMEDICINE, 2014, 9 (10) : 1487 - 1498
  • [9] An Array-based Compressed Sensing Receiver Architecture
    Bolstad, Andrew K.
    Vian, James E.
    Chisum, Jonathan D.
    Suh, Youngho
    2016 IEEE INTERNATIONAL SYMPOSIUM ON PHASED ARRAY SYSTEMS AND TECHNOLOGY (PAST), 2016,
  • [10] Array-based sensing of amyloidogenic proteins and discrimination of cancer by using different oxidants doped carbon nanodots as fluorescent probes
    Li, Qin-Ying
    Ma, Liyun
    Li, Li
    Wang, Shilin
    Li, Xi
    Zhang, Cong
    Zhang, Yu
    Jiang, Ming
    Wang, Hui
    Huang, Kun
    Yu, Xu
    Xu, Li
    CHEMICAL ENGINEERING JOURNAL, 2022, 430
12345