Properties of the corticostriatal long term depression induced by medial prefrontal cortex high frequency stimulation in vivo

被引：8

作者：

Braz, Barbara Y. ^{[1
,2
]}

Belforte, Juan E. ^{[1
,2
]}

Gustavo Murer, M. ^{[1
,2
]}

Galinanes, Gregorio L. ^{[1
,2
,3
]}

机构：

[1] Univ Buenos Aires, Fac Med, Dept Ciencias Fisiol, Grp Neurociencia Sistemas, Buenos Aires, DF, Argentina

[2] Univ Buenos Aires, CONICET, Inst Fisiol & Biofis IFIBIO Houssay, Buenos Aires, DF, Argentina

[3] Univ Geneva, CMU, Dept Fundamental Neurosci, Rue Michel Servet 1, CH-1211 Geneva 4, Switzerland

来源：

NEUROPHARMACOLOGY | 2017年 / 121卷

关键词：

Long term depression; Corticostriatal plasticity; Prefrontal cortex; Dopamine; Endocannabinoids; NMDA receptor; Striatum; SYNAPTIC PLASTICITY; STRIATAL NEURONS; DORSAL STRIATUM; DEPENDENT LTD; CHOLINERGIC INTERNEURONS; ENDOCANNABINOID RELEASE; DOPAMINERGIC CONTROL; ANESTHETIZED RATS; NMDA RECEPTORS; BASAL GANGLIA;

D O I：

10.1016/j.neuropharm.2017.05.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Repetitive stimulation of cognitive forebrain circuits at frequencies capable of inducing corticostriatal long term plasticity is increasingly being used with therapeutic purposes in patients with neuropsychiatric disorders. However, corticostriatal plasticity is rarely studied in the intact brain. Our aim was to study the mechanisms of corticostriatal long term depression (LTD) induced by high frequency stimulation (HFS) of the medial prefrontal cortex in vivo. Our main finding is that the LTD induced in the dorsomedial striatum by medial prefrontal cortex HFS in vivo (prefrontostriatal LTD) is not affected by manipulations that block or reduce the LTD induced in the dorsolateral striatum by motor cortex HFS in brain slices, including pharmacological dopamine receptor and CB1 receptor blockade, chronic nigrostriatal dopamine depletion, CB1 receptor genetic deletion and selective striatal cholinergic interneuron (SCIN) ablation. Conversely, like in the hippocampus and other brain areas, prefrontostriatal LTD is NMDA receptor dependent. Thus, we describe a novel form of corticostriatal LTD that operates in brain circuits involved in reward and cognition and could be relevant for understanding the therapeutic effects of deep brain stimulation. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：278 / 286

页数：9

共 75 条

[1] Combined activation of L-type Ca2+ channels and synaptic transmission is sufficient to induce striatal long-term depression
Adermark, Louise
Lovinger, David M.
[J]. JOURNAL OF NEUROSCIENCE, 2007, 27 (25) : 6781 - 6787
[2] Opioids induce dissociable forms of long-term depression of excitatory inputs to the dorsal striatum
Atwood, Brady K.
Kupferschmidt, David A.
Lovinger, David M.
[J]. NATURE NEUROSCIENCE, 2014, 17 (04) : 540 - U91
[3] The dopamine D4 receptor is essential for hyperactivity and impaired behavioral inhibition in a mouse model of attention deficit/hyperactivity disorder
Avale, ME
Falzone, TL
Gelman, DM
Low, MJ
Grandy, DK
Rubinstein, M
[J]. MOLECULAR PSYCHIATRY, 2004, 9 (07) : 718 - 726
[4] From prediction error to incentive salience: mesolimbic computation of reward motivation
Berridge, Kent C.
[J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2012, 35 (07) : 1124 - 1143
[5] Braz B. Y., 2015, NEUROPSYCHOPHARMACOL, P1
[6] CALABRESI P, 1994, J NEUROSCI, V14, P4871
[7] CALABRESI P, 1992, J NEUROSCI, V12, P4224
[8] LONG-TERM POTENTIATION IN THE STRIATUM IS UNMASKED BY REMOVING THE VOLTAGE-DEPENDENT MAGNESIUM BLOCK OF NMDA RECEPTOR CHANNELS
CALABRESI, P
PISANI, A
MERCURI, NB
BERNARDI, G
[J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 1992, 4 (10) : 929 - 935
[9] Postsynaptic, not presynaptic NMDA receptors are required for spike-timing-dependent LTD induction
Carter, Brett C.
Jahr, Craig E.
[J]. NATURE NEUROSCIENCE, 2016, 19 (09) : 1218 - 1224
[10] NMDA receptors are the basis for persistent network activity in neocortex slices
Castro-Alamancos, Manuel A.
Favero, Morgana
[J]. JOURNAL OF NEUROPHYSIOLOGY, 2015, 113 (10) : 3816 - 3826

← 1 2 3 4 5 6 7 8 →