Diastereoselective synthesis of polysubstituted pyrrolidinone as a key intermediate for the anticancer agents by palladium(II)-catalyzed carboxylation

被引：19

作者：

Choi, DR ^{[1
]}

Lee, KY ^{[1
]}

Chung, YS ^{[1
]}

Joo, JE ^{[1
]}

Kim, YH ^{[1
]}

Oh, CY ^{[1
]}

Lee, YS ^{[1
]}

Ham, WH ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Coll Pharm, Suwon 440746, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2005年 / 28卷 / 02期

关键词：

palladium; carboxylation; pyrrolidinone; stereocontrol;

D O I：

10.1007/BF02977706

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Palladium(II)-catalyzed carboxylation of chiral olefins 6a-d has been examined under various conditions. In the weak basic condition (K2CO3), 7a-d were obtained in good yields. Alternatively, in the strong basic condition, pyrrolidinones 8a-d were obtained resulting in excellent yields and with high diastereoselectivity.

引用

页码：151 / 158

页数：8

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