Gastrointestinal Motility and Response to Levodopa in Parkinson's Disease: A Proof-of-Concept Study

被引：5

作者：

Safarpour, Delaram ^{[1
]}

Brumbach, Barbara H. ^{[2
]}

Arena, Monica ^{[1
]}

Quinn, Joseph ^{[1
]}

Diamond, Sarah ^{[3
]}

Nutt, Jay G. ^{[1
]}

Pfeiffer, RonaldF. ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Neurol, OP-32 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[2] Oregon Hlth & Sci Univ, Biostat & Design Program, OHSU PSU Sch Publ Hlth, Portland, OR 97201 USA

[3] Oregon Hlth & Sci Univ, Dept Med, Portland, OR 97201 USA

来源：

MOVEMENT DISORDERS | 2022年 / 37卷 / 10期

关键词：

Parkinson's disease; gastrointestinal dysmotility; levodopa response; small intestinal bacterial overgrowth; gastrointestinal transit time; INTESTINAL BACTERIAL OVERGROWTH; GASTROPARESIS; DYSFUNCTION; DISORDERS; DIAGNOSIS; TRANSIT;

D O I：

10.1002/mds.29176

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background Simultaneous measurement of gastrointestinal transit time (GITT) and plasma levodopa concentration (PLC) is crucial to understanding the effect of dysfunctional motility on levodopa response in patients with Parkinson's disease (PwPD). Objective The aim is to determine if altered segmental GITT correlates with clinical response and PLC variability in PwPD. Methods Ten typical and 10 erratic responders ingested the SmartPill (SP) wireless motility capsule. Serial PLC and finger tapping, obtained every 30 minutes for 3 hours after SP/levodopa ingestion, evaluated the correlation between GITT, clinical response, and PLC. Glucose breath testing assessed small intestinal bacterial overgrowth (SIBO). Results GITT was not significantly different in "typical" and "erratic" responders. SIBO was positive in half of the erratic and negative in most typical responders. Conclusion SP is a feasible technology for assessing GITT in PwPD. A larger study may be able to significantly differentiate/correlate GITT in different segments of the GI tract with response to levodopa. (c) 2022 International Parkinson and Movement Disorder Society.

引用

页码：2153 / 2158

页数：6

共 26 条

[1] The long-duration response to levodopa: Phenomenology, potential mechanisms and clinical implications [J].