Basic science in Parkinson's disease: its impact on clinical practice

被引:5
作者
Schulz, Joerg B. [1 ,2 ]
Gerlach, Manfred
Gille, Gabriele [3 ,4 ]
Kuhn, Wilfried [5 ]
Muengersdorf, Martina [6 ]
Riederer, Peter [7 ]
Suedmeyer, Martin [8 ]
Ludolph, Albert [9 ]
机构
[1] Rhein Westfal TH Aachen, Univ Hosp, Dept Neurol, Pauwelsstr 30, D-52074 Aachen, Germany
[2] JARA Brain, Aachen, Germany
[3] Univ Wurzburg, Dept Child & Adolescent Psychiat, Psychosomat & Psychotherapy, Wurzburg, Germany
[4] Tech Univ Dresden, Dept Neurol, Dresden, Germany
[5] Leopoldina Krankenhaus, Dept Neurol, Schweinfurt, Germany
[6] Neurol Hackeschen Markt, Berlin, Germany
[7] Univ Wurzburg, Clin & Policlin Psychiat Psychosomat & Psychother, Wurzburg, Germany
[8] Univ Dusseldorf, Dept Neurol, Dusseldorf, Germany
[9] Univ Ulm, Dept Neurolgy, Oberer Eselsberg 45, D-89081 Ulm, Germany
关键词
Parkinson's disease; Basic science; History; Treatment; Genetics; RECOVERY FOLLOWING TRANSPLANTATION; FETAL NIGRAL TRANSPLANTATION; EMBRYONIC STEM-CELLS; DOPAMINERGIC-NEURONS; NIGROSTRIATAL PATHWAY; SUBSTANTIA-NIGRA; 6-OHDA LESIONS; BRAIN; STIMULATION; PATHOLOGY;
D O I
10.1007/s00415-011-6040-y
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Failures in clinical studies that were aimed to prove disease-modifying effects of treatments in Parkinson's disease (PD) raise the question as to whether basic sciences have had an impact in clinical practice. This question implies that despite well-publicized results obtained by intensive genetic and pathogenetic research, e.g. the identification of mutations and cellular biochemical pathways that underlie Parkinson-specific neurodegeneration, no relevant disease-modifying treatment options have been developed. This view neglects the fact that today there are plenty of dopaminergic and non-dopaminergic and surgical treatment options, and that PD was not treatable 50 years ago. This progress was made possible only by basic science. In this review, we underline the success of previous basic science for daily practice in PD and its impact for the understanding and development of an early diagnosis. Early, even pre-symptomatic diagnosis might be key to successfully establish disease-modifying treatments.
引用
收藏
页码:S299 / S306
页数:8
相关论文
共 50 条
[31]   Iron accumulation in Parkinson's disease [J].
Mochizuki, Hideki ;
Yasuda, Toru .
JOURNAL OF NEURAL TRANSMISSION, 2012, 119 (12) :1511-1514
[32]   Cell repair in Parkinson's disease [J].
O'Keeffe, G. ;
Barker, R. A. .
FUTURE NEUROLOGY, 2007, 2 (02) :209-217
[33]   Neuropathology of α-synuclein in Parkinson's disease [J].
Choong, Chi-Jing ;
Mochizuki, Hideki .
NEUROPATHOLOGY, 2022, 42 (02) :93-103
[34]   Machine learning on Parkinson's disease? Let's translate into clinical practice [J].
Cerasa, Antonio .
JOURNAL OF NEUROSCIENCE METHODS, 2016, 266 :161-162
[35]   Clinical translation of stem cell transplantation in Parkinson's disease [J].
Lindvall, O. .
JOURNAL OF INTERNAL MEDICINE, 2016, 279 (01) :30-40
[36]   Basic Science in Movement Disorders: Fueling the Engine of Translation into Clinical Practice [J].
Outeiro, Tiago F. ;
Kalia, Lorraine V. ;
Bezard, Erwan ;
Ferrario, Juan ;
Lin, Chin-Hsien ;
Salama, Mohamed ;
Standaert, David G. ;
Taiwo, Lolade ;
Takahashi, Ryosuke ;
Vila, Miquel ;
Mollenhauer, Brit ;
Svenningsson, Per .
MOVEMENT DISORDERS, 2024, 39 (06) :929-933
[37]   Impact of placebo assignment in clinical trials of Parkinson's disease [J].
Goetz, CG ;
Janko, K ;
Blasucci, L ;
Jaglin, JA .
MOVEMENT DISORDERS, 2003, 18 (10) :1146-1149
[38]   Impact of autonomic symptoms on the clinical course of Parkinson's disease [J].
Fujita, Hiroaki ;
Ogaki, Keitaro ;
Shiina, Tomohiko ;
Sakuramoto, Hirotaka ;
Nozawa, Narihiro ;
Suzuki, Keisuke .
NEUROLOGICAL SCIENCES, 2024, 45 (08) :3799-3807
[39]   A Guideline for Parkinson's Disease Nurse Specialists, with Recommendations for Clinical Practice [J].
Lennaerts, Herma ;
Groot, Marieke ;
Rood, Berna ;
Gilissen, Koen ;
Tulp, Hella ;
van Wensen, Erik ;
Munneke, Marten ;
van Laar, Teus ;
Bloem, Bastiaan R. .
JOURNAL OF PARKINSONS DISEASE, 2017, 7 (04) :749-754
[40]   Anhedonia and its correlation with clinical aspects in Parkinson's disease [J].
Nagayama, Hiroshi ;
Maeda, Tetsuya ;
Uchiyama, Tsuyoshi ;
Hashimoto, Masaya ;
Nomoto, Nobuatsu ;
Kano, Osamu ;
Takahashi, Tatsuya ;
Terashi, Hiroo ;
Hamada, Shinsuke ;
Hasegawa, Takafumi ;
Hatano, Taku ;
Takahashi, Tetsuya ;
Baba, Yasuhiko ;
Sengoku, Renpei ;
Watanabe, Hirohisa ;
Inoue, Manabu ;
Kadowaki, Taro ;
Kaneko, Satoshi ;
Shimura, Hideki ;
Kubo, Shin-ichiro .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2017, 372 :403-407