Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2

被引：288

作者：

Yokoi, M

Kobayashi, K

Manabe, T

Takahashi, T

Sakaguchi, I

Katsuura, G

Shigemoto, R

Ohishi, H

Nomura, S

Nakamura, K

Nakao, K

Katsuki, M

Nakanishi, S

机构：

[1] KYOTO UNIV, FAC MED, DEPT BIOL SCI, KYOTO 606, JAPAN

[2] UNIV TOKYO, FAC MED, BRAIN RES INST, DEPT NEUROPHYSIOL, TOKYO 113, JAPAN

[3] SHIONOGI & CO LTD, ABURAHI LABS, SHIGA 52034, JAPAN

[4] KYOTO UNIV, FAC MED, DEPT MORPHOL BRAIN SCI, KYOTO 606, JAPAN

[5] KYOTO UNIV, COLL MED TECHNOL, KYOTO 606, JAPAN

[6] KYUSHU UNIV, MED INST BIOREGULAT, FUKUOKA 812, JAPAN

来源：

SCIENCE | 1996年 / 273卷 / 5275期

关键词：

D O I：

10.1126/science.273.5275.645

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Subtype 2 of the metabotropic glutamate receptor (mGluR2) is expressed in the presynaptic elements of hippocampal messy fiber-GAS synapses. Knockout mice deficient in mGluR2 showed no histological changes and no alterations in basal synaptic transmission, paired-pulse facilitation, or tetanus-induced long-term potentiation (LTP) al the messy fiber-CA3 synapses. Long-term depression (LTD) induced by low-frequency stimulation, however, was almost fully abolished. The mutant mice performed normally in water maze learning tasks. Thus, the presynaptic mGluR2 is essential for inducing LTD at the mossy fiber-CA3 synapses, but this hippocampal LTD does not seem to be required for spatial learning.

引用

收藏

页码：645 / 647

页数：3

相关论文

共 24 条

[1] PKC-GAMMA MUTANT MICE EXHIBIT MILD DEFICITS IN SPATIAL AND CONTEXTUAL LEARNING [J].

ABELIOVICH, A ;

PAYLOR, R ;

CHEN, C ;

KIM, JJ ;

WEHNER, JM ;

TONEGAWA, S .

CELL, 1993, 75 (07) :1263-1271

[2] IMPAIRMENT OF SPATIAL BUT NOT CONTEXTUAL MEMORY IN CAMKII MUTANT MICE WITH A SELECTIVE LOSS OF HIPPOCAMPAL LTP IN THE RANGE OF THE THETA-FREQUENCY [J].

BEACH, ME ;

HAWKINS, RD ;

OSMAN, M ;

KANDEL, ER ;

MAYFORD, M .

CELL, 1995, 81 (06) :905-915

[3] THE ROLE OF CA2+ CHANNELS IN HIPPOCAMPAL MOSSY FIBER SYNAPTIC TRANSMISSION AND LONG-TERM POTENTIATION [J].

CASTILLO, PE ;

WEISSKOPF, MG ;

NICOLL, RA .

NEURON, 1994, 12 (02) :261-269

[4] LONG-TERM POTENTIATION OF GUINEA-PIG MOSSY FIBER RESPONSES IS NOT BLOCKED BY N-METHYL D-ASPARTATE ANTAGONISTS [J].

HARRIS, EW ;

COTMAN, CW .

NEUROSCIENCE LETTERS, 1986, 70 (01) :132-137

[5] ROLE OF A METABOTROPIC GLUTAMATE-RECEPTOR IN SYNAPTIC MODULATION IN THE ACCESSORY OLFACTORY-BULB [J].

HAYASHI, Y ;

MOMIYAMA, A ;

TAKAHASHI, T ;

OHISHI, H ;

OGAWAMEGURO, R ;

SHIGEMOTO, R ;

MIZUNO, N ;

NAKANISHI, S .

NATURE, 1993, 366 (6456) :687-690

[6] A genetic test of the effects of mutations in PKA on mossy fiber LTP and its relation to spatial and contextual learning [J].

Huang, YY ;

Kandel, ER ;

Varshavsky, L ;

Brandon, EP ;

Qi, M ;

Idzerda, RL ;

McKnight, GS ;

Bourtchouladze, R .

CELL, 1995, 83 (07) :1211-1222

[7] CAMP CONTRIBUTES TO MESSY FIBER LTP BY INITIATING BOTH A COVALENTLY MEDIATED EARLY PHASE AND MACROMOLECULAR SYNTHESIS-DEPENDENT LATE-PHASE [J].

HUANG, YY ;

LI, XC ;

KANDEL, ER .

CELL, 1994, 79 (01) :69-79

[8] Presynaptic long-term depression at the hippocampal mossy fiber-CA3 synapse [J].

Kobayashi, K ;

Manabe, T ;

Takahashi, T .

SCIENCE, 1996, 273 (5275) :648-650

[9] 2-AMINO-4-PHOSPHONOBUTYRATE SELECTIVELY BLOCKS MOSSY FIBER CA3 RESPONSES IN GUINEA-PIG BUT NOT RAT HIPPOCAMPUS [J].

LANTHORN, TH ;

GANONG, AH ;

COTMAN, CW .

BRAIN RESEARCH, 1984, 290 (01) :174-178

[10] MODULATION OF SYNAPTIC TRANSMISSION AND LONG-TERM POTENTIATION - EFFECTS ON PAIRED-PULSE FACILITATION AND EPSC VARIANCE IN THE CA1 REGION OF THE HIPPOCAMPUS [J].

MANABE, T ;

WYLLIE, DJA ;

PERKEL, DJ ;

NICOLL, RA .

JOURNAL OF NEUROPHYSIOLOGY, 1993, 70 (04) :1451-1459