Emerging Biologics in Severe Asthma

被引：11

作者：

Pavord, Ian D. ^{[1
,2
]}

Hilvering, Bart ^{[1
,2
,3
]}

Shrimanker, Rahul ^{[1
,2
]}

机构：

[1] Univ Oxford, Dept Resp Med, Old Rd, Oxford OX3 7LE, England

[2] Univ Oxford, Nuffield Dept Med, Old Rd Campus, Oxford OX3 7FZ, England

[3] Univ Med Ctr, Dept Resp Med, Lab Translat Immunol, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2016年 / 36卷 / 03期

关键词：

Severe asthma; Biomarkers; Type-2; cytokines; Anti-IL-5; Anti-IL-13; Anti-IL-4&13; OBSTRUCTIVE PULMONARY-DISEASE; SEVERE EOSINOPHILIC ASTHMA; SEVERE PERSISTENT ASTHMA; PLACEBO-CONTROLLED TRIAL; TO-SEVERE ASTHMA; DOUBLE-BLIND; MONOCLONAL-ANTIBODY; AIRWAY INFLAMMATION; SPUTUM EOSINOPHILIA; CXCR2; ANTAGONIST;

D O I：

10.1016/j.iac.2016.04.001

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Asthma is characterized by typical symptoms, variable airway obstruction and airway inflammation. Most patients with asthma are well controlled when treated with inhaled corticosteroids. However, around 10% have severe asthma, and remain symptomatic and/or at risk of asthma attacks despite maximum inhaled therapy. Identification of eosinophilic airways inflammation is particularly important as biological agents blocking interleukin (IL)-5, IL-13 and both IL-4 and 13 are effective treatments in this sub-group. The future will be identification of potentially responsive patients on the basis of biomarkers rather than arbitrary physiological patterns of disease, and targeted treatment with specific cytokine blockade.

引用

页码：609 / +

页数：16

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