Infections caused by Scedosporium spp.

被引：559

作者：

Cortez, Karoll J. ^{[1
]}

Roilides, Emmanuel ^{[1
]}

Quiroz-Telles, Flavio ^{[2
]}

Meletiadis, Joseph ^{[1
]}

Antachopoulos, Charalampos ^{[1
]}

Knudsen, Tena ^{[1
]}

Buchanan, Wendy ^{[1
]}

Milanovich, Jeffrey ^{[1
]}

Sutton, Deanna A. ^{[3
]}

Fothergill, Annette ^{[3
]}

Rinaldi, Michael G. ^{[3
]}

Shea, Yvonne R. ^{[4
]}

Zaoutis, Theoklis ^{[5
]}

Kottilil, Shyam ^{[6
]}

Walsh, Thomas J. ^{[1
]}

机构：

[1] NCI, Pediat Oncol Branch, Immunocompromised Host Sect, Bethesda, MD 20892 USA

[2] Univ Fed Parana, Hosp Clin, BR-80060000 Curitiba, Parana, Brazil

[3] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78229 USA

[4] Childrens Hosp Philadelphia, Div Infect Dis, Philadelphia, PA 19104 USA

[5] Warren G Magnuson Clin Ctr, Dept Lab Med, Microbiol Serv, Bethesda, MD USA

[6] NIAID, Immunoregulat Lab, Immunopathogenesis Sect, Bethesda, MD 20892 USA

来源：

CLINICAL MICROBIOLOGY REVIEWS | 2008年 / 21卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1128/CMR.00039-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Scedosporium spp. are increasingly recognized as causes of resistant life-threatening infections in immunocompromised patients. Scedosporium spp. also cause, a wide spectrum of conditions, including mycetoma, saprobic involvement and colonization of the airways, sinopulmonary infections, extrapulmonary localized infections, and disseminated infections. Invasive scedosporium infections are also associated with central nervous infection following near-drowning accidents. The most common sites of infection are the lungs, sinuses, bones, joints, eyes, and brain. Scedosporium apiospermum and Scedosporium prolificans are the two principal medically important species of this genus. Pseudallescheria boydii, the teleomorph of S. apiospermum, is recognized by the presence of cleistothecia. Recent advances in molecular taxonomy have advanced the understanding of the genus Scedosporium and have demonstrated a wider range of species than heretofore recognized. Studies of the pathogenesis of and immune response to Scedosporium spp. underscore the importance of innate host defenses in protection against these organisms. Microbiological diagnosis of Scedosporium spp. currently depends upon culture and morphological characterization. Molecular tools for clinical microbiological detection of Scedosporium spp. are currently investigational. Infections caused by S. apiospermum and P. boydii inpatients and animals may respond to antifungal triazoles. By comparison, infections caused by S. prolificans seldom respond to medical therapy alone. Surgery and reversal of immunosuppression may be the only effective therapeutic options for infections caused by S. prolificans.

引用

页码：157 / +

页数：42

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