Gene Expression Profiles of Estrogen Receptor-Positive and Estrogen Receptor-Negative Breast Cancers Are Detectable in Histologically Normal Breast Epithelium
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作者:
Graham, Kelly
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机构:Boston Univ, Med Ctr, Sch Med, Genet & Genom Program, Boston, MA 02118 USA
Graham, Kelly
Ge, Xijin
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机构:
S Dakota State Univ, Dept Math & Stat, Brookings, SD 57007 USABoston Univ, Med Ctr, Sch Med, Genet & Genom Program, Boston, MA 02118 USA
Ge, Xijin
[4
]
de las Morenas, Antonio
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机构:
Boston Univ, Sch Med, Dept Pathol, Boston, MA 02118 USABoston Univ, Med Ctr, Sch Med, Genet & Genom Program, Boston, MA 02118 USA
de las Morenas, Antonio
[2
]
Tripathi, Anusri
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机构:
Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USABoston Univ, Med Ctr, Sch Med, Genet & Genom Program, Boston, MA 02118 USA
Tripathi, Anusri
[3
]
Rosenberg, Carol L.
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机构:
Boston Univ, Med Ctr, Sch Med, Genet & Genom Program, Boston, MA 02118 USA
Boston Univ, Sch Med, Dept Pathol, Boston, MA 02118 USA
Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USABoston Univ, Med Ctr, Sch Med, Genet & Genom Program, Boston, MA 02118 USA
Rosenberg, Carol L.
[1
,2
,3
]
机构:
[1] Boston Univ, Med Ctr, Sch Med, Genet & Genom Program, Boston, MA 02118 USA
[2] Boston Univ, Sch Med, Dept Pathol, Boston, MA 02118 USA
[3] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA
[4] S Dakota State Univ, Dept Math & Stat, Brookings, SD 57007 USA
Purpose: Previously, we found that gene expression in histologically normal breast epithelium (NlEpi) from women at high breast cancer risk can resemble gene expression in NlEpi from cancer-containing breasts. Therefore, we hypothesized that gene expression characteristic of a cancer subtype might be seen in NlEpi of breasts containing that subtype. Experimental Design: We examined gene expression in 46 cases of microdissected NlEpi from untreated women undergoing breast cancer surgery. From 30 age-matched cases [15 estrogen receptor (ER)+, 15 ER-] we used Affymetryix U133A arrays. From 16 independent cases (9 ER+, 7 ER+), we validated selected genes using quantitative real-time PCR (qPCR). We then compared gene expression between NlEpi and invasive breast cancer using four publicly available data sets. Results: We identified 198 genes that are differentially expressed between NlEpi from breasts with ER+ (NlEpiER+) compared with ER- cancers (NlEpiER-). These include genes characteristic of ER+ and ER- cancers (e. g., ESR1, GATA3, and CX3CL1, FABP7). qPCR validated the microarray results in both the 30 original cases and the 16 independent cases. Gene expression in NlEpiER+ and NlEpiER- resembled gene expression in ER+ and ER- cancers, respectively: 25% to 53% of the genes or probes examined in four external data sets overlapped between NlEpi and the corresponding cancer subtype. Conclusions: Gene expression differs in NlEpi of breasts containing ER+ compared with ER- breast cancers. These differences echo differences in ER+ and ER- invasive cancers. NlEpi gene expression may help elucidate subtype-specific risk signatures, identify early genomic events in cancer development, and locate targets for prevention and therapy. Clin Cancer Res; 17(2); 236-46. (C)2010 AACR.
机构:
Harvard Med Sch, Massachusetts Gen Hosp, Ctr Canc, 10 N Grove St,Lawrence House 304, Boston, MA 02114 USAHarvard Med Sch, Massachusetts Gen Hosp, Ctr Canc, 10 N Grove St,Lawrence House 304, Boston, MA 02114 USA
Spring, Laura M.
Gupta, Arjun
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Univ Texas Southwestern Med Ctr, Dept Med, Dallas, TX USAHarvard Med Sch, Massachusetts Gen Hosp, Ctr Canc, 10 N Grove St,Lawrence House 304, Boston, MA 02114 USA
Gupta, Arjun
Reynolds, Kerry L.
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Harvard Med Sch, Massachusetts Gen Hosp, Ctr Canc, 10 N Grove St,Lawrence House 304, Boston, MA 02114 USAHarvard Med Sch, Massachusetts Gen Hosp, Ctr Canc, 10 N Grove St,Lawrence House 304, Boston, MA 02114 USA
Reynolds, Kerry L.
Gadd, Michele A.
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Harvard Med Sch, Massachusetts Gen Hosp, Ctr Canc, 10 N Grove St,Lawrence House 304, Boston, MA 02114 USAHarvard Med Sch, Massachusetts Gen Hosp, Ctr Canc, 10 N Grove St,Lawrence House 304, Boston, MA 02114 USA
Gadd, Michele A.
Ellisen, Leif W.
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Harvard Med Sch, Massachusetts Gen Hosp, Ctr Canc, 10 N Grove St,Lawrence House 304, Boston, MA 02114 USAHarvard Med Sch, Massachusetts Gen Hosp, Ctr Canc, 10 N Grove St,Lawrence House 304, Boston, MA 02114 USA
Ellisen, Leif W.
Isakoff, Steven J.
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Harvard Med Sch, Massachusetts Gen Hosp, Ctr Canc, 10 N Grove St,Lawrence House 304, Boston, MA 02114 USAHarvard Med Sch, Massachusetts Gen Hosp, Ctr Canc, 10 N Grove St,Lawrence House 304, Boston, MA 02114 USA
Isakoff, Steven J.
Moy, Beverly
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Harvard Med Sch, Massachusetts Gen Hosp, Ctr Canc, 10 N Grove St,Lawrence House 304, Boston, MA 02114 USAHarvard Med Sch, Massachusetts Gen Hosp, Ctr Canc, 10 N Grove St,Lawrence House 304, Boston, MA 02114 USA
Moy, Beverly
Bardia, Aditya
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Harvard Med Sch, Massachusetts Gen Hosp, Ctr Canc, 10 N Grove St,Lawrence House 304, Boston, MA 02114 USAHarvard Med Sch, Massachusetts Gen Hosp, Ctr Canc, 10 N Grove St,Lawrence House 304, Boston, MA 02114 USA
机构:
Univ Arizona, Canc Biol Grad Interdisciplinary Program, Tucson, AZ 85724 USAUniv Arizona, Canc Biol Grad Interdisciplinary Program, Tucson, AZ 85724 USA
Cheng, Julia N.
Frye, Jennifer B.
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Univ Arizona, Dept Med, Tucson, AZ 85724 USAUniv Arizona, Canc Biol Grad Interdisciplinary Program, Tucson, AZ 85724 USA
Frye, Jennifer B.
Whitman, Susan A.
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Univ Arizona, Dept Med, Tucson, AZ 85724 USAUniv Arizona, Canc Biol Grad Interdisciplinary Program, Tucson, AZ 85724 USA
Whitman, Susan A.
Kunihiro, Andrew G.
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Univ Arizona, Dept Nutr Sci, Tucson, AZ 85724 USAUniv Arizona, Canc Biol Grad Interdisciplinary Program, Tucson, AZ 85724 USA
Kunihiro, Andrew G.
Pandey, Ritu
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Univ Arizona, Dept Cellular & Mol Med, Tucson, AZ 85724 USAUniv Arizona, Canc Biol Grad Interdisciplinary Program, Tucson, AZ 85724 USA
Pandey, Ritu
Funk, Janet L.
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机构:
Univ Arizona, Dept Med, Tucson, AZ 85724 USA
Univ Arizona, Dept Nutr Sci, Tucson, AZ 85724 USAUniv Arizona, Canc Biol Grad Interdisciplinary Program, Tucson, AZ 85724 USA
机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, New York, NY 10065 USA
Schwartz, Christopher J.
Marra, Antonio
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Mem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, New York, NY 10065 USA
Marra, Antonio
Selenica, Pier
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Mem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, New York, NY 10065 USA
Selenica, Pier
Gazzo, Andrea
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Mem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, New York, NY 10065 USA
Gazzo, Andrea
Tan, Kiki
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Mem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, New York, NY 10065 USA
Tan, Kiki
Ross, Dara
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Mem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, New York, NY 10065 USA
Ross, Dara
Razavi, Pedram
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Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY USAMem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, New York, NY 10065 USA
Razavi, Pedram
Chandarlapaty, Sarat
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Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY USAMem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, New York, NY 10065 USA
Chandarlapaty, Sarat
Weigelt, Britta
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Mem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, New York, NY 10065 USA
Weigelt, Britta
Reis-Filho, Jorge S.
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Mem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, New York, NY 10065 USA
AstraZeneca, Gaithersburg, MD USAMem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, New York, NY 10065 USA
Reis-Filho, Jorge S.
Brogi, Edi
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Mem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, New York, NY 10065 USA
Brogi, Edi
Pareja, Fresia
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Mem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, New York, NY 10065 USA
Pareja, Fresia
Wen, Hannah Y.
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Mem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, New York, NY 10065 USA
机构:
SUNY Stony Brook, Sch Med, Dept Pathol, New York, NY 11794 USASUNY Stony Brook, Sch Med, Dept Pathol, New York, NY 11794 USA
Merkin, Ross D.
Vanner, Elizabeth A.
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SUNY Stony Brook, Sch Med, Dept Pathol, New York, NY 11794 USA
SUNY Stony Brook, Sch Med, Dept Biomed Informat, New York, NY 11794 USASUNY Stony Brook, Sch Med, Dept Pathol, New York, NY 11794 USA
Vanner, Elizabeth A.
Romeiser, Jamie L.
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SUNY Stony Brook, Sch Med, Dept Surg, New York, NY 11794 USASUNY Stony Brook, Sch Med, Dept Pathol, New York, NY 11794 USA
Romeiser, Jamie L.
Shroyer, A. Laurie W.
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SUNY Stony Brook, Sch Med, Dept Surg, New York, NY 11794 USASUNY Stony Brook, Sch Med, Dept Pathol, New York, NY 11794 USA
Shroyer, A. Laurie W.
Escobar-Hoyos, Luisa F.
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SUNY Stony Brook, Sch Med, Dept Pathol, New York, NY 11794 USASUNY Stony Brook, Sch Med, Dept Pathol, New York, NY 11794 USA
Escobar-Hoyos, Luisa F.
Li, Jinyu
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SUNY Stony Brook, Sch Med, Dept Pathol, New York, NY 11794 USASUNY Stony Brook, Sch Med, Dept Pathol, New York, NY 11794 USA
Li, Jinyu
Powers, Robert S.
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SUNY Stony Brook, Sch Med, Dept Pathol, New York, NY 11794 USASUNY Stony Brook, Sch Med, Dept Pathol, New York, NY 11794 USA
Powers, Robert S.
Burke, Stephanie
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SUNY Stony Brook, Sch Med, Dept Pathol, New York, NY 11794 USASUNY Stony Brook, Sch Med, Dept Pathol, New York, NY 11794 USA
Burke, Stephanie
Shroyer, Kenneth R.
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SUNY Stony Brook, Sch Med, Dept Pathol, New York, NY 11794 USASUNY Stony Brook, Sch Med, Dept Pathol, New York, NY 11794 USA
机构:
Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Hong Kong, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Hong Kong, Hong Kong, Peoples R China
Tsang, Julia Y. S.
Ni, Yun-Bi
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Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Hong Kong, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Hong Kong, Hong Kong, Peoples R China
Ni, Yun-Bi
Chan, Siu-Ki
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Kwong Wah Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Hong Kong, Hong Kong, Peoples R China
Chan, Siu-Ki
Shao, Mu-Min
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机构:
Guangzhou Univ Tradit, Shenzhen Affiliated Hosp, Dept Pathol, Shenzhen, Peoples R ChinaChinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Hong Kong, Hong Kong, Peoples R China
Shao, Mu-Min
Law, Bonita K. B.
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机构:
Union Hosp, Breast Ctr, Hong Kong, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Hong Kong, Hong Kong, Peoples R China
Law, Bonita K. B.
Tan, Puay Hoon
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机构:
Singapore Gen Hosp, Dept Pathol, Singapore, SingaporeChinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Hong Kong, Hong Kong, Peoples R China
Tan, Puay Hoon
Tse, Gary M.
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机构:
Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Hong Kong, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Hong Kong, Hong Kong, Peoples R China
机构:
Northwestern Univ, Feinberg Sch Med, Dept Surg, 303 Super Str,Lurie 4-111, Chicago, IL 60611 USANorthwestern Univ, Feinberg Sch Med, Dept Surg, 303 Super Str,Lurie 4-111, Chicago, IL 60611 USA
Wang, Jun
Shidfar, Ali
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Northwestern Univ, Feinberg Sch Med, Dept Surg, 303 Super Str,Lurie 4-111, Chicago, IL 60611 USANorthwestern Univ, Feinberg Sch Med, Dept Surg, 303 Super Str,Lurie 4-111, Chicago, IL 60611 USA
Shidfar, Ali
Ivancic, David
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Northwestern Univ, Feinberg Sch Med, Dept Surg, 303 Super Str,Lurie 4-111, Chicago, IL 60611 USANorthwestern Univ, Feinberg Sch Med, Dept Surg, 303 Super Str,Lurie 4-111, Chicago, IL 60611 USA
Ivancic, David
Ranjan, Manish
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Northwestern Univ, Feinberg Sch Med, Dept Surg, 303 Super Str,Lurie 4-111, Chicago, IL 60611 USANorthwestern Univ, Feinberg Sch Med, Dept Surg, 303 Super Str,Lurie 4-111, Chicago, IL 60611 USA
Ranjan, Manish
Liu, Liannian
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Northwestern Univ, Feinberg Sch Med, Dept Surg, 303 Super Str,Lurie 4-111, Chicago, IL 60611 USANorthwestern Univ, Feinberg Sch Med, Dept Surg, 303 Super Str,Lurie 4-111, Chicago, IL 60611 USA
Liu, Liannian
Choi, Mi-Ran
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Northwestern Univ, Feinberg Sch Med, Dept Surg, 303 Super Str,Lurie 4-111, Chicago, IL 60611 USANorthwestern Univ, Feinberg Sch Med, Dept Surg, 303 Super Str,Lurie 4-111, Chicago, IL 60611 USA
Choi, Mi-Ran
Parimi, Vamsi
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Northwestern Univ, Feinberg Sch Med, Dept Pathol, 303 Super Str,Lurie 4-111, Chicago, IL 60611 USANorthwestern Univ, Feinberg Sch Med, Dept Surg, 303 Super Str,Lurie 4-111, Chicago, IL 60611 USA
Parimi, Vamsi
Gursel, Demirkan B.
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Northwestern Univ, Feinberg Sch Med, Dept Pathol, 303 Super Str,Lurie 4-111, Chicago, IL 60611 USANorthwestern Univ, Feinberg Sch Med, Dept Surg, 303 Super Str,Lurie 4-111, Chicago, IL 60611 USA
Gursel, Demirkan B.
Sullivan, Megan E.
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Northwestern Univ, Feinberg Sch Med, Dept Pathol, 303 Super Str,Lurie 4-111, Chicago, IL 60611 USANorthwestern Univ, Feinberg Sch Med, Dept Surg, 303 Super Str,Lurie 4-111, Chicago, IL 60611 USA
Sullivan, Megan E.
Najor, Matthew S.
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机构:
Rush Univ, Med Ctr, Dept Med, Chicago, IL 60612 USANorthwestern Univ, Feinberg Sch Med, Dept Surg, 303 Super Str,Lurie 4-111, Chicago, IL 60611 USA
Najor, Matthew S.
Abukhdeir, Abde M.
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机构:
Rush Univ, Med Ctr, Dept Med, Chicago, IL 60612 USA
Rush Univ, Med Ctr, Dept Pharmacol, Chicago, IL 60612 USANorthwestern Univ, Feinberg Sch Med, Dept Surg, 303 Super Str,Lurie 4-111, Chicago, IL 60611 USA
Abukhdeir, Abde M.
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Scholtens, Denise
Khan, Seema A.
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机构:
Northwestern Univ, Feinberg Sch Med, Dept Surg, 303 Super Str,Lurie 4-111, Chicago, IL 60611 USA
Northwestern Univ, Feinberg Sch Med, Robert H Lurie Comprehens Canc Ctr, 303 Super Str,Lurie 4-111, Chicago, IL 60611 USANorthwestern Univ, Feinberg Sch Med, Dept Surg, 303 Super Str,Lurie 4-111, Chicago, IL 60611 USA
机构:
Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol, Houston, TX 77030 USA
Univ Texas MD Anderson Canc Ctr, Clin Canc Genet Program, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, 1515 Holcombe Blvd,Box 108, Houston, TX 77030 USA
Arun, Banu
Seewaldt, Victoria L.
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City Hope Natl Med Ctr, Dept Populat Sci, Duarte, CA USA
City Hope Natl Med Ctr, Comprehens Canc Ctr, Duarte, CA USAUniv Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, 1515 Holcombe Blvd,Box 108, Houston, TX 77030 USA
Seewaldt, Victoria L.
Yu, Dihua
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机构:
Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, 1515 Holcombe Blvd,Box 108, Houston, TX 77030 USA
Univ Texas Houston, Grad Sch Biomed Sci Houston, Canc Biol Program, Houston, TX USA
China Med Univ, Ctr Mol Med, Taichung, TaiwanUniv Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, 1515 Holcombe Blvd,Box 108, Houston, TX 77030 USA