Magnetically Guided Theranostics: Optimizing Magnetic Resonance Imaging with Sandwich-Like Kaolinite-Based Iron/Platinum Nanoparticles for Magnetic Fluid Hyperthermia and Chemotherapy

被引:34
作者
Chan, Ming-Hsien [1 ]
Hsieh, Ming-Ren [2 ,3 ]
Liu, Ru-Shi [1 ,2 ,3 ,4 ]
Wei, Da-Hua [2 ,3 ]
Hsiao, Michael [1 ,5 ]
机构
[1] Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan
[2] Natl Taipei Univ Technol, Grad Inst Mfg Technol, Taipei 106, Taiwan
[3] Natl Taipei Univ Technol, Dept Mech Engn, Taipei 106, Taiwan
[4] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan
[5] Kaohsiung Med Univ, Coll Med, Dept Biochem, Kaohsiung 807, Taiwan
关键词
SUPERPARAMAGNETIC FEPT NANOPARTICLES; ONE-POT SYNTHESIS; OXYGEN REDUCTION; CONGO RED; IN-VITRO; NANOCOMPOSITES; DELIVERY; CLAY; VIVO;
D O I
10.1021/acs.chemmater.9b03552
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Hepatocellular carcinoma (HCC) is a common type of liver cancer that can be diagnosed by magnetic resonance imaging (MRI). If diagnosing HCC by basic MRI is difficult, then doctors use T-1-weighted or T-2-weighted imaging with a contrast agent that has long-term retention in the liver, such as Fe3O4 or FePt, to aid in MRI diagnosis. One challenging goal of cancer prevention is developing a method that can further treat or inhibit HCC cells at the time of diagnosis. Functionalized porous kaolinite can serve not only as a drug delivery system for treating cancer cells but also as a scaffold to carry FePt nanoparticles (FePt NPs) and drugs such as doxorubicin (Dox). FePt NPs combined with kaolinite modified with cetyltrimethylammonium bromide (CTAB) can form FePt@Kao nanocomposites. Multifunctional FePt@Kao can serve as a magnetic fluid hyperthermia (MFH) agent that can also be used to simultaneously visualize and treat HCC cancer cells. After being loaded with the chemotherapeutic drug Dox, FePt@Kao-Dox can provide both MFH treatment and chemotherapy. From the systematic analysis results, we demonstrated that this functionalized FePt@Kao-Dox nanocomposite can be successfully used as a platform to integrate MRI, magnetically guided targeting, and therapeutic treatment into a multifunctional drug delivery system.
引用
收藏
页码:697 / 708
页数:12
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