Effects of microgravity and bone morphogenetic protein II on GFAP in rat brain

被引：20
作者：
Day, JR [1 ]
Frank, AT
O'Callaghan, JP
DeHart, BW
机构：
[1] Penn State Univ, Erwin Mueller Lab 208, Dept Biol, University Pk, PA 16802 USA
[2] NIOSH, Ctr Dis Control & Prevent, Hlth Effects Lab Div, Morgantown, WV 26505 USA
来源：
JOURNAL OF APPLIED PHYSIOLOGY | 1998年 / 85卷 / 02期
关键词：
hippocampus; spaceflight; stress; glucocorticoids; astrocytes; glial fibrillary acidic protein;
D O I：
10.1152/jappl.1998.85.2.716
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
This study evaluated effects of bone morphogenetic protein II (BMP) on glial fibrillary acidic protein (GFAP) in the brain of female Fischer 344 rats during 14 days of spaceflight. GFAP mRNA decreased in vehicle-implanted rats flown on the space shuttle by 53 and 48% in the stratum moleculare and stratum lacunosum moleculare hippocampal subregions, respectively. GFAP mRNA was not significantly affected by BMP implantation during spaceflight. Rats returning from space exhibited a 56% increase in serum corticosterone. BMP treatment did not additively increase corticosterone elevations in microgravity but appeared to increase serum corticosterone and reduce GFAP mRNA in the stratum moleculare in control rats. These data suggest that exposure to microgravity reduces GFAP expression in hippocampal astrocytes.
引用
收藏
页码：716 / 722
页数：7
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