Individual-level PM2.5 exposure and the time course of impaired heart rate variability: the APACR Study

被引:60
作者
He, Fan [1 ]
Shaffer, Michele L. [1 ]
Li, Xian [1 ]
Rodriguez-Colon, Sol [1 ]
Wolbrette, Deborah L. [2 ]
Williams, Ronald [3 ]
Cascio, Wayne E. [4 ,5 ]
Liao, Duanping [1 ]
机构
[1] Penn State Univ, Coll Med, Dept Publ Hlth Sci, Hershey, PA 17033 USA
[2] Penn State Univ, Coll Med, Dept Med, Div Cardiol, Hershey, PA 17033 USA
[3] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA
[4] E Carolina Univ, Brody Sch Med, Dept Cardiovasc Sci, Greenville, NC USA
[5] E Carolina Univ, E Carolina Heart Inst, Greenville, NC USA
关键词
particulate matter; fine particles; heart rate variability; autonomic modulation; cardiovascular disease; personal nephelometry; PARTICULATE AIR-POLLUTION; CARDIAC AUTONOMIC CONTROL; CORONARY-ARTERY-DISEASE; ENVIRONMENTAL EPIDEMIOLOGY; CARDIOVASCULAR-DISEASE; CRITERIA POLLUTANTS; SUDDEN-DEATH; INFLAMMATION; POPULATION; ASSOCIATION;
D O I
10.1038/jes.2010.21
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
In 106 community-dwelling middle-aged non-smokers we examined the time-course and the acute effects of fine particles (PM2.5) on heart rate variability (HRV), which measures cardiac autonomic modulation (CAM). Twenty-four hours beat-to-beat ECG data were visually examined. Artifacts and arrhythmic beats were removed. Normal beat-to-beat RR data were used to calculate HRV indices. Personal PM2.5 nephelometry was used to estimate 24-h individual-level real-time PM2.5 exposures. We use linear mixed-effects models to assess autocorrelation- and other major confounder-adjusted regression coefficients between 1-6 h moving averages of PM2.5 and HRV indices. The increases in preceding 1-6 h moving averages of PM2.5 was significantly associated with lower HF, LF, and SDNN, with the largest effect size at 4-6 h moving averages and smallest effects size at 1 h moving average. For example, a 10 mu g/m(3) increase in 1 and 6-h moving averages was associated with 0.027 and 0.068 ms(2) decrease in log-HF, respectively, and with 0.024 and 0.071 ms(2) decrease in log-LF, respectively, and with 0.81 and 1.75 ms decrease in SDNN, respectively (all P-values <0.05). PM2.5 exposures are associated with immediate impairment of CAM. With a time-course of within 6 h after elevated PM2.5 exposure, with the largest effects around 4-6 h. Journal of Exposure Science and Environmental Epidemiology (2011) 21, 65-73; doi: 10.1038/jes.2010.21; published online 7 April 2010
引用
收藏
页码:65 / 73
页数:9
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