Cancer - Awakening angels

被引：52

作者：

Lane, D ^{[1
]}

机构：

[1] Univ Dundee, Dept Biochem, Canc Res Campaign Labs, Dundee DD1 4HN, Scotland

来源：

NATURE | 1998年 / 394卷 / 6694期

关键词：

D O I：

10.1038/29166

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

When mammalian cells are under stress they activate the tumour-suppressor gene p53. But how does the cell signal to p53 that it is under attack? A new study implicates the DNA-dependent protein kinase (DNA-PK), which is activated by DNA damage and can bind p53. Damaged cells that don't contain DNA-PK accumulate an inactive form of p53, indicating that DNA-PK is crucial for the activation of p53.

引用

页码：616 / 617

页数：2

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