Graphene Oxide Nanosheets with Efficient Antibacterial Activity Against Methicillin-Resistant Staphylococcus aureus (MRSA)

被引：13

作者：

Gao, Yujie ^{[1
,2
]}

Dong, Yuanhao ^{[1
]}

Cao, Yubin ^{[1
,3
]}

Huang, Wenlong ^{[1
]}

Yu, Chenhao ^{[1
]}

Sui, Shangyan ^{[1
]}

Mo, Anchun ^{[2
]}

Peng, Qiang ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis, Chengdu 610041, Peoples R China

[2] Sichuan Univ, West China Hosp Stomatol, Dept Oral Implantol, Chengdu 610041, Peoples R China

[3] Sichuan Univ, West China Hosp Stomatol, Dept Oral & Maxillofaci3I Surg, Chengdu 610041, Peoples R China

来源：

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2021年 / 17卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Nanomaterials; Graphene Oxide; Antibacterial; MRSA; Infection; DRUG-DELIVERY; NANOPARTICLES; NANOMATERIALS; POTENTIALS; ADSORPTION;

D O I：

10.1166/jbn.2021.3123

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The development of drug-resistant bacteria has become a public health problem, among which methicillin-resistant Staphylococcus aureus (MRSA) leads to various life-threatening diseases. Graphene oxide (GO) is a two-dimensional nanomaterial with potential in the anti-MRSA treatment. This study prepared GO nanosheets with fixed lamellar size, investigated its antibacterial activity against MRSA, and analyzed the related antibacterial mechanisms. We found that the fabrication of GO with stable dispersion was workable. Furthermore, such GO had superior antibacterial performance against MRSA at low concentrations with the dose-dependent anti-MRSA effect. The GO-MRSA interaction also provided fundamental support for the antibacterial mechanisms with cleavage and encapsulation effects. In conclusion, GO nanosheets may be a promising antimicrobial agent against MRSA.

引用

页码：1627 / 1634

页数：8

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