Antinociceptive tolerance to the mu-opioid agonist DAMGO is dose-dependently reduced by MK-801 in rats
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Mao, JR
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Virginia Commonwealth Univ, Med Coll Virginia, Dept Anesthesiol, Richmond, VA 23298 USAVirginia Commonwealth Univ, Med Coll Virginia, Dept Anesthesiol, Richmond, VA 23298 USA
Mao, JR
[1
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Price, DD
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Virginia Commonwealth Univ, Med Coll Virginia, Dept Anesthesiol, Richmond, VA 23298 USAVirginia Commonwealth Univ, Med Coll Virginia, Dept Anesthesiol, Richmond, VA 23298 USA
Price, DD
[1
]
Lu, J
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Virginia Commonwealth Univ, Med Coll Virginia, Dept Anesthesiol, Richmond, VA 23298 USAVirginia Commonwealth Univ, Med Coll Virginia, Dept Anesthesiol, Richmond, VA 23298 USA
Lu, J
[1
]
Mayer, DJ
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Virginia Commonwealth Univ, Med Coll Virginia, Dept Anesthesiol, Richmond, VA 23298 USAVirginia Commonwealth Univ, Med Coll Virginia, Dept Anesthesiol, Richmond, VA 23298 USA
Mayer, DJ
[1
]
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[1] Virginia Commonwealth Univ, Med Coll Virginia, Dept Anesthesiol, Richmond, VA 23298 USA
Morphine has been used in previous studies that investigate interactions between the spinal cord mu-opioid and N-methyl-D-aspartate (NMDA) receptors in mechanisms of antinociceptive tolerance. Although morphine acts primarily on the cc-receptor, it also activates other subtypes of opioid receptors. In the present study, the selective mu-opioid agonist, D-Ala(2)-N-Me-Phe(4),Gly-ol(5-)enkephalin (DAMGO), was used to further test the hypothesis. Repeated intrathecal (i.t.) administration of 6 mu g DAMGO (twice daily) in rats for 7 days resulted in an approximately 17-fold rightward shift of the cumulative dose-response curve (the tail-flick test) on Day 8 compared to that on Day 1. This rightward shift of the dose-response curve was prevented by the i.t. coadministration with DAMGO of the NMDA receptor antagonist MK-801 (10 = 5 > 2.5 >> 1.25 nmol > saline). Further, a lower dose range of MK-801 (2.5 > 1.25 nmol > 0.625 > 0.313 = saline) was effective to prevent the antinociceptive tolerance to a lower dose (1.5 mu g) of DAMGO using the same i.t, administration regimen. Thus, the present results provide further evidence supporting a cellular and intracellular model of opioid tolerance involving interactions between the mu-opioid and the NMDA receptors in the spinal cord. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
机构:
Univ Iowa, Grad Program Neurosci, Iowa City, IA 52242 USA
Univ Iowa, Med Scientist Training Program, Iowa City, IA 52242 USAUniv Iowa, Dept Anesthesia, Iowa City, IA 52242 USA
Jongeling, Amy C.
Johns, Malcolm E.
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Georgia State Univ, Ctr Behav Neurosci, Inst Neurosci, Atlanta, GA 30302 USAUniv Iowa, Dept Anesthesia, Iowa City, IA 52242 USA
Johns, Malcolm E.
Murphy, Anne Z.
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Georgia State Univ, Ctr Behav Neurosci, Inst Neurosci, Atlanta, GA 30302 USAUniv Iowa, Dept Anesthesia, Iowa City, IA 52242 USA
Murphy, Anne Z.
Hammond, Donna L.
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Univ Iowa, Dept Anesthesia, Iowa City, IA 52242 USA
Univ Iowa, Grad Program Neurosci, Iowa City, IA 52242 USAUniv Iowa, Dept Anesthesia, Iowa City, IA 52242 USA
机构:
Univ Mississippi, Med Ctr, Dept Psychiat & Human Behav, 2500 N State St, Jackson, MS 39216 USAUniv Mississippi, Med Ctr, Dept Psychiat & Human Behav, 2500 N State St, Jackson, MS 39216 USA
Zamarripa, C. Austin
Edwards, Shelley R.
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Millsaps Coll, Dept Psychol & Neurosci, Jackson, MS 39210 USAUniv Mississippi, Med Ctr, Dept Psychiat & Human Behav, 2500 N State St, Jackson, MS 39216 USA
Edwards, Shelley R.
Qureshi, Hina N.
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Millsaps Coll, Dept Psychol & Neurosci, Jackson, MS 39210 USAUniv Mississippi, Med Ctr, Dept Psychiat & Human Behav, 2500 N State St, Jackson, MS 39216 USA
Qureshi, Hina N.
Yi, John N.
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Univ Mississippi, Med Ctr, Dept Psychiat & Human Behav, 2500 N State St, Jackson, MS 39216 USAUniv Mississippi, Med Ctr, Dept Psychiat & Human Behav, 2500 N State St, Jackson, MS 39216 USA
Yi, John N.
Blough, Bruce E.
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Res Triangle Inst, Ctr Drug Discovery, POB 12194, Res Triangle Pk, NC 27709 USAUniv Mississippi, Med Ctr, Dept Psychiat & Human Behav, 2500 N State St, Jackson, MS 39216 USA
Blough, Bruce E.
Freeman, Kevin B.
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Univ Mississippi, Med Ctr, Dept Psychiat & Human Behav, 2500 N State St, Jackson, MS 39216 USAUniv Mississippi, Med Ctr, Dept Psychiat & Human Behav, 2500 N State St, Jackson, MS 39216 USA
机构:
Temple Univ, Lewis Katz Sch Med, Dept Neural Sci, Ctr Subst Abuse Res CSAR, Philadelphia, PA 19122 USA
Temple Univ Hosp & Med Sch, Dept Gastroenterol & Hepatol, Philadelphia, PA USATemple Univ, Lewis Katz Sch Med, Dept Neural Sci, Ctr Subst Abuse Res CSAR, Philadelphia, PA 19122 USA
Reichenbach, Zachary W.
DiMattio, Kelly
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Temple Univ, Lewis Katz Sch Med, Dept Neural Sci, Ctr Subst Abuse Res CSAR, Philadelphia, PA 19122 USATemple Univ, Lewis Katz Sch Med, Dept Neural Sci, Ctr Subst Abuse Res CSAR, Philadelphia, PA 19122 USA
DiMattio, Kelly
Rajakaruna, Suren
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Temple Univ, Lewis Katz Sch Med, Ctr Inflammat Translat & Clin Lung Res, Philadelphia, PA USATemple Univ, Lewis Katz Sch Med, Dept Neural Sci, Ctr Subst Abuse Res CSAR, Philadelphia, PA 19122 USA
Rajakaruna, Suren
Ambrose, David
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Temple Univ, Lewis Katz Sch Med, Ctr Inflammat Translat & Clin Lung Res, Philadelphia, PA USATemple Univ, Lewis Katz Sch Med, Dept Neural Sci, Ctr Subst Abuse Res CSAR, Philadelphia, PA 19122 USA
Ambrose, David
Cornwell, William D.
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Temple Univ, Lewis Katz Sch Med, Ctr Inflammat Translat & Clin Lung Res, Philadelphia, PA USATemple Univ, Lewis Katz Sch Med, Dept Neural Sci, Ctr Subst Abuse Res CSAR, Philadelphia, PA 19122 USA
Cornwell, William D.
Tallarida, Ronald J.
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Temple Univ, Lewis Katz Sch Med, Dept Neural Sci, Ctr Subst Abuse Res CSAR, Philadelphia, PA 19122 USATemple Univ, Lewis Katz Sch Med, Dept Neural Sci, Ctr Subst Abuse Res CSAR, Philadelphia, PA 19122 USA
Tallarida, Ronald J.
Rogers, Thomas
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Temple Univ, Lewis Katz Sch Med, Ctr Inflammat Translat & Clin Lung Res, Philadelphia, PA USATemple Univ, Lewis Katz Sch Med, Dept Neural Sci, Ctr Subst Abuse Res CSAR, Philadelphia, PA 19122 USA
Rogers, Thomas
Liu-Chen, Lee-Yuan
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Temple Univ, Lewis Katz Sch Med, Dept Neural Sci, Ctr Subst Abuse Res CSAR, Philadelphia, PA 19122 USATemple Univ, Lewis Katz Sch Med, Dept Neural Sci, Ctr Subst Abuse Res CSAR, Philadelphia, PA 19122 USA
Liu-Chen, Lee-Yuan
Tuma, Ronald F.
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Temple Univ, Lewis Katz Sch Med, Dept Neural Sci, Ctr Subst Abuse Res CSAR, Philadelphia, PA 19122 USATemple Univ, Lewis Katz Sch Med, Dept Neural Sci, Ctr Subst Abuse Res CSAR, Philadelphia, PA 19122 USA
Tuma, Ronald F.
Ward, Sara Jane
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Temple Univ, Lewis Katz Sch Med, Dept Neural Sci, Ctr Subst Abuse Res CSAR, Philadelphia, PA 19122 USATemple Univ, Lewis Katz Sch Med, Dept Neural Sci, Ctr Subst Abuse Res CSAR, Philadelphia, PA 19122 USA
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Univ Iowa, Coll Pharm, Div Med & Nat Prod Chem, Iowa City, IA 52242 USAUniv Kansas, Dept Med Chem, Lawrence, KS 66045 USA
Lamb, Kenneth
Tidgewell, Kevin
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Univ Iowa, Coll Pharm, Div Med & Nat Prod Chem, Iowa City, IA 52242 USAUniv Kansas, Dept Med Chem, Lawrence, KS 66045 USA
Tidgewell, Kevin
Simpson, Denise S.
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Univ Kansas, Dept Med Chem, Lawrence, KS 66045 USAUniv Kansas, Dept Med Chem, Lawrence, KS 66045 USA
Simpson, Denise S.
Bohn, Laura M.
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Scripps Res Inst, Dept Mol Therapeut, Jupiter, FL 33458 USAUniv Kansas, Dept Med Chem, Lawrence, KS 66045 USA
Bohn, Laura M.
Prisinzano, Thomas E.
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Univ Kansas, Dept Med Chem, Lawrence, KS 66045 USA
Univ Iowa, Coll Pharm, Div Med & Nat Prod Chem, Iowa City, IA 52242 USAUniv Kansas, Dept Med Chem, Lawrence, KS 66045 USA