Effects of beta-cypermethrin on male rat reproductive system

被引：30

作者：

Liu, Lu ^{[1
]}

Hu, Jin-xia ^{[1
]}

Wang, He ^{[1
]}

Chen, Bao-jun ^{[1
]}

He, Zhen ^{[1
]}

Xu, Li-chun ^{[1
]}

机构：

[1] Xuzhou Med Coll, Sch Publ Hlth, Xuzhou 221002, Jiangsu, Peoples R China

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2010年 / 30卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Endocrine disrupting; Beta-cypermethrin; Androgen receptors; Spermatogenesis; Pesticide; RECEPTOR TRANSCRIPTIONAL ACTIVITIES; ALTERS SEXUAL-DIFFERENTIATION; ANDROGEN-RECEPTOR; IN-VIVO; ENVIRONMENTAL ANTIANDROGENS; PYRETHROID PESTICIDES; MOLECULAR-MECHANISMS; BISPHENOL-A; EXPOSURE; FENVALERATE;

D O I：

10.1016/j.etap.2010.06.007

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

To study adverse effects and underlying mechanisms of beta-cypermethrin (beta-cyp) on male reproductive system, the 15-day intact male adult Sprague-Dawley (SD) rats assay was used as an in vivo test. Male adult SD rats were treated by oral gavage with 0, 15 and 30 mg beta-cyp/kg BW for 15 days. After 15-day treatments, the testes, epididymis and seminal vesicles were excised and weighed, respectively. One testis was used for testicular sperm head counts, and the other was for immunohistochemistry test to characterize the expression of androgen receptors (ARs). There were substantial decreases of both sperm head counts and daily sperm production after beta-cyp exposure. The expression of AR decreased significantly in rats treated with 15 and 30 mg beta-cyp/kg BW, and the gray scale pixel values in the three groups (0, 15 and 30 mg beta-cyp/kg BW) were 113.79 +/- 13.58, 96.09 +/- 5.95 and 77.27 +/- 5.44, respectively. These findings suggested beta-cyp has significant adverse effects on the reproductive system. Reducing the expression of AR is a potential mechanism of decreased sperm production caused by beta-cyp. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：251 / 256

页数：6

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