The detection of Mycoplasma pneumoniae in nasal polyps

被引：8
作者：
Gurr, PA
Chakraverty, A
Callanan, V
Gurr, SJ
机构：
[1] UNIV OXFORD,OXFORD,ENGLAND
[2] GUYS & ST THOMAS HOSP,LONDON SE1 9RT,ENGLAND
来源：
CLINICAL OTOLARYNGOLOGY | 1996年 / 21卷 / 03期
关键词：
nasal polyps; rhinosinusitis; obstructive turbinates; Mycoplasma pneumoniae; PCR;
D O I：
10.1111/j.1365-2273.1996.tb01739.x
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
The aetiology and microbial flora of nasal polyps is not well understood. No study in the literature has reported an association between the sub-bacterium Mycoplasma pneumoniae and nasal polyps. We have developed an assay method using the Polymerase Chain Reaction (PCR) to amplify a specific region of the M. pneumoniae DNA in extracts of clinical samples using species-specific primers designed to a region of the 16S rRNA. The presence of M. pneumoniae was detected in 13/14 (93%) nasal polyps, in 4/5 (80%) rhinosinusitis mucosal samples but only in 1/7 (14%) of control samples (obstructive turbinates). An epidemic of infections due to M, pneumoniae is expected to occur in 1995. We believe this assay could form the basis of a rapid technique for M. pneumoniae detection. We also propose that the presence of M. pneumoniae may be of importance in the aetiology of nasal polyps.
引用
收藏
页码：269 / 273
页数：5
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