Assessment of Pancreatic Iron Overload in Transfusion Dependent Thalassemic Patients

被引:1
作者
Hashemieh, Mozhgan [1 ]
机构
[1] Shahid Beheshti Univ Med Sci, Imam Hossein Med Ctr, Tehran, Iran
关键词
Iron overload; Magnetic Resonance Imaging; Pancreas; Thalassemia; MAGNETIC-RESONANCE; MAJOR PATIENTS; CHELATION-THERAPY; CARDIAC IRON; LIVER IRON; TOTAL-BODY; HEART; DEFERASIROX; BURDEN;
D O I
10.18502/ijpho.v9i4.1575
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Advances in the management of transfusion dependent thalassemic patients have improved the survival of these patients. The most important consequence of repeated and frequent transfusions is iron accumulation in vital organs. The magnetic resonance imaging (MRI) is a non-invasive and valid technique for the estimation of iron stores. Despite multiple studies about cardiac and liver MRI T2*, there is limited experience about pancreatic MRI. Although there is a weak correlation between hepatic and pancreatic siderosis, MRI assessment of iron deposition in the pancreas can reduce cardiac morbidity. Pancreatic siderosis may be a predictor for the development of glucose dysregulation. Pancreatic R2* > 100 Hz is a risk factor for glucose intolerance or even overt diabetes. Splenectomy can accentuate the pancreatic iron overload. Early intensive chelation therapy in thalassemia patients can reverse glucose metabolism impairment. In this review, the MRI assessment of pancreatic iron overload in transfusion dependent thalassemia, the correlation between pancreas with liver and myocardial hemosiderosis and the importance of pancreatic iron overload in pathogenesis of diabetes mellitus in these patients were discussed.
引用
收藏
页码:264 / 270
页数:7
相关论文
共 41 条
[1]   Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload [J].
Anderson, LJ ;
Holden, S ;
Davis, B ;
Prescott, E ;
Charrier, CC ;
Bunce, NH ;
Firmin, DN ;
Wonke, B ;
Porter, J ;
Walker, JM ;
Pennell, DJ .
EUROPEAN HEART JOURNAL, 2001, 22 (23) :2171-2179
[2]   MRI evaluation of tissue iron burden in patients with β-thalassaemia major [J].
Argyropoulou, Maria I. ;
Astrakas, Loukas .
PEDIATRIC RADIOLOGY, 2007, 37 (12) :1191-1200
[3]   Liver, bone marrow, pancreas and pituitary gland iron overload in young and adult thalassemic patients: a T2 relaxometry study [J].
Argyropoulou, Maria I. ;
Kiortsis, Dimitrios N. ;
Astrakas, Loukas ;
Metafratzi, Zafiria ;
Chalissos, Nikolaos ;
Efremidis, Stavros C. .
EUROPEAN RADIOLOGY, 2007, 17 (12) :3025-3030
[4]   A T2*magnetic resonance imaging study of pancreatic iron overload in thalassemia major [J].
Au, Wing-Yan ;
Lam, Wynnie Wai-Man ;
Chu, Winnie ;
Tam, Sidney ;
Wong, Wai-Keng ;
Liang, Raymond ;
Ha, Shau-Yin .
HAEMATOLOGICA, 2007, 93 (01) :116-119
[5]  
Azarkeivan A, 2016, ARCH IRAN MED, V19, P96, DOI 0161902/AIM.006
[6]  
de Assis RA, 2011, EINSTEIN-SAO PAULO, V9, P165, DOI [10.1590/S1679-45082011AO1897, 10.1590/s1679-45082011ao1897]
[7]   Pancreatic iron stores assessed by magnetic resonance imaging (MRI) in beta thalassemic patients [J].
de Assis, Reijane Alves ;
Feitosa Ribeiro, Andreza Alice ;
Kay, Fernando Uliana ;
Rosemberg, Laercio Alberto ;
Nomura, Cesar Higa ;
Loggetto, Sandra Regina ;
Araujod, Aderson S. ;
Fabron, Antonio Junior ;
de Almeida Verissimo, Monica Pinheiro ;
Baldanzi, Giorgio Roberto ;
Esposito, Breno Pannia ;
Baroni, Ronaldo Hueb ;
Wood, John C. ;
Hamerschlak, Nelson .
EUROPEAN JOURNAL OF RADIOLOGY, 2012, 81 (07) :1465-1470
[8]  
De Sanctis Vincenzo, 2004, Pediatr Endocrinol Rev, V2 Suppl 2, P249
[9]   Effect of enhanced iron chelation therapy on glucose metabolism in patients with β-thalassaemia major [J].
Farmaki, Kalistheni ;
Angelopoulos, Nicholas ;
Anagnostopoulos, George ;
Gotsis, Efstathios ;
Rombopoulos, Grigorios ;
Tolis, George .
BRITISH JOURNAL OF HAEMATOLOGY, 2006, 134 (04) :438-444
[10]   Beta-thalassemia [J].
Galanello, Renzo ;
Origa, Raffaella .
ORPHANET JOURNAL OF RARE DISEASES, 2010, 5