Voltammetric and spectrophotometric study on the complexation of glibenclamide with β-cyclodextrin

被引：12

作者：

Radi, Abd-Elgawad ^{[1
]}

Eissa, Shimaa ^{[1
]}

机构：

[1] Mansoura Univ, Dept Chem, Fac Sci Dumyat, Dumyat 34517, Egypt

来源：

JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2010年 / 68卷 / 3-4期

关键词：

Cyclodextrin; Glibenclamide; Spectrophotometry; Voltammetry; GLYBURIDE SOLUBILITY; DISSOLUTION;

D O I：

10.1007/s10847-010-9801-9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The formation of an inclusion complex of glibenclamide (GL) with beta-cyclodextrin (beta-CD) in an aqueous ethanolic buffer solution of pH 7.0 has been investigated by UV spectrophotometry and differential pulse voltammetry and its stability constant is determined to be 855 and 354.15 M-1, respectively. The phase solubility profile, based on the spectrophotometric absorbance's variations, was classified as A(L)-type, indicating the formation of 1:1 stoichiometric inclusion complex of glibenclamide with beta-CD with a stability constant value, K (S), of 846 M-1.

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收藏

页码：417 / 421

页数：5

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