Synthesis of iron oxide nanorods for enhanced magnetic hyperthermia

被引:51
|
作者
Nikitin, Aleksey [1 ,2 ]
Khramtsov, Maxim [1 ]
Garanina, Anastasiia [1 ,2 ]
Mogilnikov, Pavel [1 ]
Sviridenkova, Natalya [1 ]
Shchetinin, Igor [1 ]
Savchenko, Alexander [1 ]
Abakumov, Maxim [1 ,3 ]
Majouga, Alexander [2 ,4 ]
机构
[1] Natl Univ Sci & Technol MISIS, Leninskiy Prospect 4, Moscow 119991, Russia
[2] Lomonosov Moscow State Univ, Dept Chem, Leninskiye Gory 1-3,GSP 1, Moscow 119991, Russia
[3] Pirogov Russian Natl Res Med Univ, Ostrovityanova 1, Moscow 117997, Russia
[4] Dmitry Mendeleev Univ Chem Technol Russia, Miusskaya Sq 9, Moscow 125047, Russia
关键词
Nanoparticles; Iron oxide; Nanorods; Hyperthermia; ABSORPTION RATE; NANOPARTICLES; CELLS; SHAPE; SIZE; MRI;
D O I
10.1016/j.jmmm.2018.09.014
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Magnetic hyperthermia is one of the most effective methods for treatment of cancer. In this work we discuss synthesis of magnetic iron oxide nanorods (IONRds) and their application for enhanced magnetic hyperthermia. By microwave irradiation the monodisperse water-soluble IONRds with clear morphology were obtained. Magnetic measurements showed that such IONRds have high value of coercivity (141 Oe). Moreover, hyperthermia experiments with synthesized samples were carried out. At the frequency and field strength of alternating magnetic field (AMF) f = 261 kHz H = 20 kA m(-1) the specific absorption rate (SAR) and intrinsic loss power (ILP) values were equal to 147 W g(-1) and 1.4 nHm(2) kg(-1) respectively, which confirms the efficiency of synthesized nanorods in hyperthermia applications.
引用
收藏
页码:443 / 449
页数:7
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