Cholesterol in platelet biogenesis and activation

被引：80
作者：
Wang, Nan [1 ]
Tall, Alan R. [1 ]
机构：
[1] Columbia Univ, Med Ctr, Dept Med, Div Mol Med, 630 W 168th St, New York, NY 10032 USA
来源：
BLOOD | 2016年 / 127卷 / 16期
基金：
美国国家卫生研究院;
关键词：
BINDING CASSETTE TRANSPORTERS; SCAVENGER RECEPTOR BI; NEUTROPHIL EXTRACELLULAR TRAPS; SR-BI; HEMATOPOIETIC STEM; MACROPHAGE ABCA1; OXIDIZED LDL; LIPID RAFTS; ATHEROSCLEROSIS; LIPOPROTEIN;
D O I：
10.1182/blood-2016-01-631259
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hypercholesterolemia is a risk factor for atherothrombotic disease, largely attributed to its impact on atherosclerotic lesional cells such as macrophages. Platelets are involved in immunity and inflammation and impact atherogenesis, primarily by modulating immune and inflammatory effector cells. There is evidence that hypercholesterolemia increases the risk of atherosclerosis and thrombosis by modulating platelet biogenesis and activity. This review highlights recent findings on the impact of aberrant cholesterol metabolism on platelet biogenesis and activity and their relevance in atherosclerosis and thrombosis.
引用
收藏
页码：1949 / 1953
页数：5
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