NaHS•nH2O-induced umpolung: the synthesis of 2-acyl-3-aminoindoles from aryl methyl ketones and 2-aminobenzonitriles

被引：23

作者：

Geng, Xiao ^{[1
]}

Wu, Xia ^{[1
]}

Wang, Can ^{[1
]}

Zhao, Peng ^{[1
]}

Zhou, You ^{[1
]}

Sun, Xuan ^{[1
]}

Wang, Ling-Jiao ^{[1
]}

Guan, Wen-Juan ^{[1
]}

Wu, Yan-Dong ^{[1
]}

Wu, An-Xin ^{[1
]}

机构：

[1] Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 90期

基金：

中国国家自然科学基金;

关键词：

C-C BOND; ESCHENMOSER COUPLING REACTION; CATALYZED SYNTHESIS; SUBSTITUTED QUINOLINES; EFFICIENT SYNTHESIS; ALKYL-HALIDES; ONE-POT; SULFUR; CONSTRUCTION; DERIVATIVES;

D O I：

10.1039/c8cc07599a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient method for constructing 2-acyl-3-aminoindoles from methyl ketones and 2-aminobenzonitriles is described, in which NaHS center dot nH(2)O is used as a novel umpolung reagent for the first time in organic synthesis. Mechanistic studies revealed that the key step involved an Eschenmoser sulfide contraction reaction.

引用

页码：12730 / 12733

页数：4

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