Is the risk of low birth weight or preterm labor greater when maternal stress is experienced during pregnancy? A systematic review and meta-analysis of cohort studies

被引:75
作者
Molina Lima, Silvana Andrea [1 ]
El Dib, Regina Paolucci [2 ]
Kron Rodrigues, Meline Rossetto [3 ]
Rago Ferraz, Guilherme Augusto [3 ]
Molina, Ana Claudia [4 ]
Pilan Neto, Carlos Alberto [5 ]
Ferraz de Lima, Marcelo Aparecido [6 ]
Cunha Rudge, Marilza Vieira [3 ]
机构
[1] UNESP Univ Estadual Paulista, Botucatu Med Sch, Nursing Dept, Botucatu, SP, Brazil
[2] UNESP, Dept Biosci & Oral Diag, Inst Sci & Technol, Sao Jose Dos Campos, Brazil
[3] Univ Estadual Paulista, UNESP, Botucatu Med Sch, Nursing Dept Gynecol & Obstet, Botucatu, SP, Brazil
[4] Municipal Author Botucatu, Sao Paulo, Brazil
[5] Univ Fed Minas Gerais, Minas Gerais Med Sch, Belo Horizonte, MG, Brazil
[6] Botucatu Med Sch, Dept Collect Hlth, Botucatu, SP, Brazil
来源
PLOS ONE | 2018年 / 13卷 / 07期
关键词
PRENATAL STRESS; PROBLEM BEHAVIOR; CORTISOL-LEVELS; ANXIETY; HEALTH; TEMPERAMENT; DEPRESSION; PREDICTION; RECEPTORS; DISTRESS;
D O I
10.1371/journal.pone.0200594
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Antenatal stress is linked to fetal risks that increase the chances of neonatal complications and reduction of child cognitive ability. Therefore, we aimed to evaluate if maternal stress affects fetal, neonatal or child development. The following databases were searched: MEDLINE (1966 to May 2016), Embase (1980 to May 2016), LILACS (1982 to May 2016) and CENTRAL (1972 to May 2016). Observational studies published in English and Portuguese were included whether there was any relationship between fetal and neonatal outcome, such as birth weight, preterm labor, child development with pregnant women that were subjected to any stress type during at least one month of follow-up. Two independent reviewers screened eligible articles, extracted data and assessed the risk of bias. Thus, 8 cohort studies with about 8,271 pregnant women and 1,081,151 children proved eligible. Results suggested a significant association between antenatal stress exposure and increasing rates of low birth weight (Odds ratio (OR) 1.68 [95% Confidential Interval (CI) 1.19, 2.38]). However, there was no statistically significance difference between non-exposed and exposed groups related to preterm labor (OR 1.98 [95% CI 0.91 to 4.31]; I2 = 68%, p = 0.04). Although, results were inconsistent with primary analysis suggesting a significant association between antenatal stress exposure and the occurrence of higher rates of preterm birth (OR 1.42 [95% CI 1.05 to 1.91]; I2 = 68%, p = 0.04) in the sensitivity analysis. Furthermore, the current review has suggested that stress perceived during antenatal negatively influences fetal life and child development. Yet, further studies are necessary with adequate sample size and longer follow-up time to confirm our findings.
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页数:15
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