Oral submucous fibrosis: An update on pathophysiology of malignant transformation

被引：42

作者：

Arakeri, Gururaj ^{[1
]}

Patil, Shekar Gowda ^{[2
]}

Aljabab, Abdulsalam S. ^{[3
]}

Lin, Kuan-Chou ^{[4
]}

Merkx, M. A. W. ^{[5
]}

Gao, Shan ^{[6
,7
,8
]}

Brennan, Peter A. ^{[9
]}

机构：

[1] Navodaya Dent Coll & Hosp, Dept Oral & Maxillofacial Surg, Raichur, India

[2] HCG Canc Hosp, Dept Med Oncol, Bangalore, Karnataka, India

[3] King Saud Univ, King Fahad Med City, Fac Dent, Dept Dent, Riyadh, Saudi Arabia

[4] Wan Fang Hosp, Dept Oral & Maxillofacial Surg, Taipei, Taiwan

[5] Radboud Univ Nijmegen, Med Ctr, Dept Oral & Maxillofacial Surg, Nijmegen, Netherlands

[6] Suzhou Ribo Life Sci Co Ltd, Kunshan City, Jiangsu, Peoples R China

[7] Cent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China

[8] Cent S Univ, Sch Stomatol, Changsha, Hunan, Peoples R China

[9] Queen Alexandra Hosp, Dept Oral & Maxillofacial Surg, Portsmouth, Hants, England

来源：

JOURNAL OF ORAL PATHOLOGY & MEDICINE | 2017年 / 46卷 / 06期

关键词：

malignant transformation; oral submucous fibrosis; review; squamous cell carcinoma; ARECA NUT; EPITHELIAL DYSPLASIA; BUCCAL MUCOSA; IN-VITRO; PATHOGENESIS; CANCER; ARECOLINE; ETIOLOGY; FIBROBLASTS; MECHANISMS;

D O I：

10.1111/jop.12582

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Oral submucous fibrosis (OSMF) is a potentially malignant condition associated with areca nut chewing. Formerly confined to the Indian subcontinent, it is now often seen in Asian populations of the United Kingdom, USA and other developed countries, and is therefore a serious problem for global health. What makes it more sinister is the malignant transformation rate, which has been reported to be around 7.6% over a 17-year period. In this concise article, we review the current trends in the pathophysiology of malignant transformation of OSMF.

引用

页码：413 / 417

页数：5

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