Catalytic Asymmetric Reductive Amination of α-Branched Ketones

被引：120

作者：

Wakchaure, Vijay N. ^{[1
]}

Zhou, Jian ^{[1
]}

Hoffmann, Sebastian ^{[1
]}

List, Benjamin ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 27期

关键词：

asymmetric catalysis; chiral amines; ketones; organocatalysis; reductive amination; DYNAMIC KINETIC RESOLUTION; BRONSTED ACID CATALYST; TRANSFER HYDROGENATION; SUBSTITUTED SPIROPIPERIDINES; ENANTIOSELECTIVE REDUCTION; ORGANOCATALYTIC REDUCTION; AROMATIC KETIMINES; PHOSPHORIC-ACID; IMINO ESTERS; AMINO-ACIDS;

D O I：

10.1002/anie.201001715

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chemical equcation Presented Branching out: An organocatalytic reductive amination of -αbranched ketones using dynamic kinetic resolution is reported. The e/s-2-substituted cyclohexyl amines were obtained in high diastereoselectivity and enantioselectivity from the corresponding ketones. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4612 / 4614

页数：3

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