Chiral β-amino acid derivatives via asymmetric hydrogenation

被引：94

作者：

Drexler, HJ ^{[1
]}

You, JS ^{[1
]}

Zhang, SL ^{[1
]}

Fischer, C ^{[1
]}

Baumann, W ^{[1
]}

Spannenberg, A ^{[1
]}

Heller, D ^{[1
]}

机构：

[1] Univ Rostock, Inst Organ Katalyseforsch, D-18055 Rostock, Germany

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2003年 / 7卷 / 03期

关键词：

D O I：

10.1021/op034011z

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

This contribution gives an overview of the synthesis of chiral b-amino acids via asymmetric hydrogenation of the corresponding dehydroamino derivatives. Literature results are discussed regarding substrate synthesis and catalyst performance and how it is affected by substrate and catalyst structure as well as experimental parameters. A tentative mechanistic concept for the hydrogenation step is also presented.

引用

页码：355 / 361

页数：7

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