TSLP: from allergy to cancer

被引：171

作者：

Corren, Jonathan ^{[1
,2
]}

Ziegler, Steven F. ^{[3
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pediat, Div Allergy & Clin Immunol, Los Angeles, CA 90095 USA

[3] Benaroya Res Inst, Immunol Program, Seattle, WA 98101 USA

来源：

NATURE IMMUNOLOGY | 2019年 / 20卷 / 12期

关键词：

THYMIC STROMAL LYMPHOPOIETIN; ACUTE LYMPHOBLASTIC-LEUKEMIA; CD4(+) T-CELLS; RESPIRATORY SYNCYTIAL VIRUS; GENOME-WIDE ASSOCIATION; INNATE LYMPHOID-CELLS; IGM(+) B-CELLS; MOLECULAR-CLONING; DENDRITIC CELLS; EPITHELIAL-CELLS;

D O I：

10.1038/s41590-019-0524-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The cytokine TSLP has been shown to be a key factor in maintaining immune homeostasis and regulating inflammatory responses at mucosal barriers. While the role of TSLP in type 2 immune responses has been investigated extensively, recent studies have found an expanding role for TSLP in inflammatory diseases and cancer. In this Review, we will highlight major recent advances in TSLP biology, along with results from emerging clinical trials of anti-TSLP agents used for the treatment of a variety of inflammatory conditions.

引用

页码：1603 / 1609

页数：7

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