Solid phase synthesis of phosphinopeptoids as transition state analog inhibitors

被引：16

作者：

Dorff, PH ^{[1
]}

Chiu, G ^{[1
]}

Goldstein, SW ^{[1
]}

Morgan, BP ^{[1
]}

机构：

[1] Pfizer Inc, Div Cent Res, Groton, CT 06340 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 21期

关键词：

D O I：

10.1016/S0040-4039(98)00496-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A procedure for preparing novel phosphinopeptoids, 1, on a solid support is described. The key step in the synthesis includes a conjugate addition of the trivalent form of a protected aminomethylphosphinic acid (5) to a resin-bound acrylate. (C) 1998 Elsevier Science Ltd. All rights reserved.

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收藏

页码：3375 / 3378

页数：4

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