Recent advances on small-molecule fluorophores with emission beyond 1000 nm for better molecular imaging in vivo

被引：81

作者：

Tu, Le ^{[1
]}

Xu, Yuling ^{[2
]}

Ouyang, Qingying ^{[2
]}

Li, Xiangyang ^{[3
]}

Sun, Yao ^{[2
]}

机构：

[1] China Univ Petr, Coll Chem, Qingdao 266555, Shandong, Peoples R China

[2] Cent China Normal Univ, Coll Chem, Key Lab Pesticides & Chem Biol,Minist Educ, Int Joint Res Ctr Intelligent Biosensor Technol &, Wuhan 430079, Hubei, Peoples R China

[3] Guizhou Univ, Minist Educ, Key Lab Green Pesticide & Agr Bioengn, State Key Lab Breeding Base Green Pesticide & Agr, Guiyang 550025, Guizhou, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2019年 / 30卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Small-molecule fluorophores; The second near-infrared channel; Benzo-bisthiadiazole; Biomedical imaging; NEAR-INFRARED WINDOW; POLYMER NANOPARTICLES; CONJUGATED POLYMER; FLUORESCENT-PROBES; RATIONAL DESIGN; II FLUOROPHORES; TUMOR; DIKETOPYRROLOPYRROLE; NANOMATERIALS; BRIGHT;

D O I：

10.1016/j.cclet.2019.05.022

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the second near-infrared channel (NIR-II, 1000-1700 nm), organic and inorganic fluorophores are designed with superior chemical/optical properties to provide real-time information with deeper penetration depth and higher resolution owing to the innate lower light scattering and absorption of the NIR-II imaging than conventional optical imaging. Among them, the small-molecule based fluorophores have been highlighted due to their desirable biocompatibility and favorable pharmacokinetics. In this review, we introduced the latest research progress of the rational design of small-molecule NIR-II fluorophores and their impressively biological applications including the NIR-II signal imaging, multimodal imaging and theranostic. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：1731 / 1737

页数：7

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