Genetic effects on educational attainment in Hungary

被引：4

作者：

Ujma, Peter P. ^{[1
,2
]}

Eszlari, Nora ^{[3
,4
]}

Millinghoffer, Andras ^{[4
,5
]}

Bruncsics, Bence ^{[5
]}

Torok, Dora ^{[3
]}

Petschner, Peter ^{[3
,6
]}

Antal, Peter ^{[5
]}

Deakin, Bill ^{[7
,8
,9
]}

Breen, Gerome ^{[10
]}

Bagdy, Gyorgy ^{[3
,4
,6
]}

Juhasz, Gabriella ^{[3
,11
]}

机构：

[1] Semmelweis Univ, Inst Behav Sci, H-1089 Budapest, Hungary

[2] Natl Inst Clin Neurosci, Budapest, Hungary

[3] Semmelweis Univ, Dept Pharmacodynam, Fac Pharm, Budapest, Hungary

[4] Semmelweis Univ, NAP SE New Antidepresst Target Res Grp 2, Hungarian Brain Res Program, Budapest, Hungary

[5] Budapest Univ Technol & Econ, Dept Measurement & Informat Syst, Budapest, Hungary

[6] Semmelweis Univ, Hungarian Acad Sci, MTA SE Neuropsychopharmacol & Neurochem Res Grp, Budapest, Hungary

[7] Univ Manchester, Fac Biol Med & Hlth, Div Neurosci & Expt Psychol, Manchester, Lancs, England

[8] Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England

[9] Greater Manchester Mental Hlth NHS Fdn Trust, Manchester, Lancs, England

[10] Kings Coll London, Social Genet & Dev Psychiat Ctr, London, England

[11] Semmelweis Univ, Hungarian Brain Res Program, SE NAP Genet Brain Imaging Migraine Res Grp 2, Budapest, Hungary

来源：

BRAIN AND BEHAVIOR | 2022年 / 12卷 / 01期

关键词：

cognitive abilities; gene-environment interaction; heritability; polygenic score; socioeconomic status; GENOME-WIDE ASSOCIATION; LIFE EVENTS; HERITABILITY; ACHIEVEMENT;

D O I：

10.1002/brb3.2430

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Introduction Educational attainment is a substantially heritable trait, and it has recently been linked to specific genetic variants by genome-wide association studies (GWASs). However, the effects of such genetic variants are expected to vary across environments, including countries and historical eras. Methods We used polygenic scores (PGSs) to assess molecular genetic effects on educational attainment in Hungary, a country in the Central Eastern European region where behavioral genetic studies are in general scarce and molecular genetic studies of educational attainment have not been previously published. Results We found that the PGS is significantly associated with the attainment of a college degree as well as the number of years in education in a sample of Hungarian study participants (N = 829). PGS effect sizes were not significantly different when compared to an English (N = 976) comparison sample with identical measurement protocols. In line with previous Estonian findings, we found higher PGS effect sizes in Hungarian, but not in English participants who attended higher education after the fall of Communism, although we lacked statistical power for this effect to reach significance. Discussion Our results provide evidence that polygenic scores for educational attainment have predictive value in culturally diverse European populations.

引用

页数：11

共 43 条

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