Nanoparticulate matter exposure results in neuroinflammatory changes in the corpus callosum

被引：40

作者：

Babadjouni, Robin ^{[1
]}

Patel, Arati ^{[1
]}

Liu, Qinghai ^{[1
]}

Shkirkova, Kristina ^{[1
]}

Lamorie-Foote, Krista ^{[1
]}

Connor, Michelle ^{[1
]}

Hodis, Drew M. ^{[1
]}

Cheng, Hank ^{[4
]}

Sioutas, Constantinos ^{[3
]}

Morgan, Todd E. ^{[4
]}

Finch, Caleb E. ^{[4
]}

Mack, William J. ^{[1
,2
]}

机构：

[1] Univ Southern Calif, Keck Sch Med, Zilkha Neurogenet Inst, Los Angeles, CA 90007 USA

[2] Univ Southern Calif, Keck Sch Med, Dept Neurosurg, Los Angeles, CA USA

[3] Univ Southern Calif, Viterbi Sch Engn, Dept Civil & Environm Engn, Los Angeles, CA USA

[4] Univ Southern Calif, Leonard Davis Sch Gerontol, Los Angeles, CA USA

来源：

PLOS ONE | 2018年 / 13卷 / 11期

基金：

美国国家卫生研究院;

关键词：

DIESEL EXHAUST PARTICLES; CENTRAL-NERVOUS-SYSTEM; AIR-POLLUTION; PARTICULATE MATTER; C5A RECEPTOR; DOPAMINERGIC NEURODEGENERATION; MICROGLIAL ACTIVATION; MULTIPLE-SCLEROSIS; COGNITIVE FUNCTION; NADPH OXIDASE;

D O I：

10.1371/journal.pone.0206934

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Epidemiological studies have established an association between air pollution particulate matter exposure (PM2.5) and neurocognitive decline. Experimental data suggest that microglia play an essential role in air pollution PM-induced neuroinflammation and oxidative stress. This study examined the effect of nano-sized particulate matter (nPM) on complement C5 deposition and microglial activation in the corpus callosum of mice (C57BLJ6J males). nPM was collected in an urban Los Angeles region impacted by traffic emissions. Mice were exposed to 10 weeks of re-aerosolized nPM or filtered air for a cumulative 150 hours. nPM-exposed mice exhibited reactive microglia and 2-fold increased local deposition of complement C5/ C5a proteins and complement component C5a receptor 1 (CD88) in the corpus callosum. However, serum C5 levels did not differ between nPM and filtered air cohorts. These findings demonstrate white matter C5 deposition and microglial activation secondary to nPM exposure. The C5 upregulation appears to be localized to the brain.

引用

页数：15

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