Psychedelic symptoms of cannabis and cocaine use as a function of trait impulsivity

被引:19
作者
van Wel, J. H. P. [1 ]
Spronk, D. B. [2 ,3 ]
Kuypers, K. P. C. [1 ]
Theunissen, E. L. [1 ]
Toennes, S. W. [4 ]
Verkes, R. J. [2 ,3 ]
Ramaekers, J. G. [1 ]
机构
[1] Maastricht Univ, Fac Psychol & Neurosci, Dept Neuropsychol & Psychopharmacol, NL-6229 ER Maastricht, Netherlands
[2] Radboud Univ Nijmegen, Med Ctr, Dept Psychiat 966, NL-6525 ED Nijmegen, Netherlands
[3] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, NL-6525 ED Nijmegen, Netherlands
[4] Goethe Univ Frankfurt, Inst Legal Med, Dept Forens Toxicol, D-60054 Frankfurt, Germany
关键词
Cocaine; cannabis; subjective intoxication; addiction; impulsivity; D-AMPHETAMINE; ORAL COCAINE; DOPAMINE; THC; DELTA(9)-TETRAHYDROCANNABINOL; MARIJUANA; HUMANS; SYSTEM; DELTA-9-TETRAHYDROCANNABINOL; VULNERABILITY;
D O I
10.1177/0269881114563633
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Trait impulsivity has been linked to addiction in humans. It has been suggested that drug users with high trait impulsivity levels are more sensitive to subjective drug intoxication. This study assessed whether subjective response to drugs differs between drug users with normal or high levels of trait impulsivity. Regular drug users (N = 122) received doses of cocaine HCl, cannabis, and placebo in a three-way crossover study. Their mood, dissociative state, and psychedelic symptoms were measured with subjective rating scales (CADDS, Bowdle, POMS). Trait impulsivity was assessed with the Barratt Impulsiveness Scale. Cannabis increased dissociation and psychedelic state, as well as fatigue, confusion, depression and anxiety, and decreased arousal, positive mood, vigor, friendliness, and elation. Cocaine increased dissociation, psychedelic state, vigor, friendliness, elation, positive mood, anxiety and arousal, while decreasing fatigue. Only a few subjective items revealed a drug x trait impulsivity interaction, suggesting that psychedelic symptoms were most intense in high impulsivity subjects. Trait impulsiveness ratings were negatively correlated with ratings of vigor (r = -.197) and positively correlated with ratings of loss of thought control (r = .237) during cannabis intoxication. It is concluded that a broad association between trait impulsivity and psychedelic subjective drug experience appears to be absent.
引用
收藏
页码:324 / 334
页数:11
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