The human microbiome

被引：139

作者：

Blum, Hubert E. ^{[1
]}

机构：

[1] Univ Hosp Freiburg, Dept Med 2, Hugstetter Str 55, D-79106 Freiburg, Germany

来源：

ADVANCES IN MEDICAL SCIENCES | 2017年 / 62卷 / 02期

关键词：

Microbiota; Fecal transplantation; Inflammatory bowel disease; Obesity; Atherosclerosis; Neurodegenerative diseases; HUMAN GUT MICROBIOME; INFLAMMATORY-BOWEL-DISEASE; RANDOMIZED CONTROLLED-TRIAL; ACTIVE ULCERATIVE-COLITIS; GENOME-WIDE ASSOCIATION; FECAL MICROBIOTA; INTESTINAL MICROBIOTA; PARKINSONS-DISEASE; CLOSTRIDIUM-DIFFICILE; INSULIN SENSITIVITY;

D O I：

10.1016/j.advms.2017.04.005

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Until recently, human microbiology was based on the identification of single microbes, such as bacteria, fungi and viruses, frequently isolated from patients with acute or chronic infections. Novel culture-independent molecular biochemical analyses (genomics, transcriptomics, proteomics, metabolomics) allow today to detect and classify the diverse microorganisms in a given ecosystem (microbiota), such as the gastrointestinal tract, the skin, the airway system, the urogenital tract and others, and to assess all genomes in these ecosystems (microbiome) as well as their gene products. These analyses revealed that each individual has its own microbiota that plays a role in health and disease. In addition, they greatly contributed to the recent advances in the understanding of the pathogenesis of a wide range of human diseases. It is to be expected that these new insights will translate into diagnostic, therapeutic and preventive measures in the context of personalized/precision medicine. (C) 2017 Medical University of Bialystok. Published by Elsevier B.V. All rights reserved.

引用

页码：414 / 420

页数：7

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