Magnetic Resonance Cancer Nanotheranostics

被引：2

作者：

Orel, V. E. ^{[1
,2
]}

Tselepi, M. ^{[3
,8
]}

Mitrelias, T. ^{[3
]}

Shevchenko, A. D. ^{[4
]}

Rykhalskiy, O. Y. ^{[1
,2
]}

Golovko, T. S. ^{[5
]}

Ganich, O. V. ^{[5
]}

Romanov, A. V. ^{[1
]}

Orel, V. B. ^{[6
]}

Burlaka, A. P. ^{[7
]}

Lukin, S. N. ^{[7
]}

Barnes, C. H. W. ^{[3
]}

机构：

[1] Natl Canc Inst, Med Phys & Bioengn Res Lab, Kiev, Ukraine

[2] Igor Sikorsky Kyiv Polytech Inst, Dept Biomed Engn, Kiev, Ukraine

[3] Univ Cambridge, Cavendish Lab, JJ Thomson Ave, Cambridge, England

[4] GV Kurdyumov Inst Met Phys, Kiev, Ukraine

[5] Natl Canc Inst, Res Dept Radiodiagnost, Kiev, Ukraine

[6] Bogomolets Natl Med Univ, Kiev, Ukraine

[7] NAS Ukraine, RE Kavetsky Inst Expt Pathol Oncol & Radiobiol, Kiev, Ukraine

[8] Univ Ioannina, Dept Phys, Ioannina, Greece

来源：

WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING 2018, VOL 3 | 2019年 / 68卷 / 03期

关键词：

Magnetic resonance; Magnetic nanocomplex; Doxorubicin; Tumor;

D O I：

10.1007/978-981-10-9023-3_120

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

It is well known that the magnetic spin effects during nanotherapy can cause tumor cell apoptosis and necrosis based on redox reactions. The current study was carried out on C57Bl/6 mice with Lewis lung carcinoma. The magnetic nanocomplex administration combined with the impact of magnetic resonance system (1.5 T) showed maximal antitumor and antimetastatic effects. The electron spin resonance spectra have been used as diagnostic markers and recorded a change in the tumor redox state based on chemical species such as NO-FeS-proteins and ubisemiquinone. The technology of magnetic resonance nanotheranostics could potentially allow to improve the antitumor effect of chemotherapeutic agents in disseminated cancer therapy.

引用

页码：651 / 654

页数：4

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