Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study

被引：8

作者：

Steiner, Kevin L. ^{[1
]}

Kabir, Mamun ^{[2
]}

Priest, Jeffrey W. ^{[3
]}

Hossain, Biplob ^{[2
]}

Gilchrist, Carol A. ^{[1
]}

Cook, Heather ^{[4
]}

Ma, Jennie Z. ^{[5
]}

Korpe, Poonum S. ^{[6
]}

Ahmed, Tahmeed ^{[2
]}

Faruque, A. S. G. ^{[2
]}

Haque, Rashidul ^{[2
]}

Petri, William A., Jr. ^{[1
]}

机构：

[1] Univ Virginia, Dept Med, Div Infect Dis & Int Hlth, Charlottesville, VA USA

[2] Icddr B, Dhaka, Bangladesh

[3] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Foodborne Waterborne & Environm Dis, Atlanta, GA USA

[4] Univ Virginia, Sch Med, Dept Stat, Charlottesville, VA 22908 USA

[5] Univ Virginia, Sch Med, Dept Publ Hlth Sci, Div Biostat, Charlottesville, VA 22908 USA

[6] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

来源：

CLINICAL INFECTIOUS DISEASES | 2020年 / 70卷 / 02期

基金：

比尔及梅琳达.盖茨基金会; 美国国家卫生研究院;

关键词：

cryptosporidiosis; mucosal; fecal; IgA; Cp23; DEVELOPING-COUNTRIES; BIRTH COHORT; ANTIBODY; CHILDREN; INFECTION; AMEBIASIS; RESPONSES; INFANTS;

D O I：

10.1093/cid/ciz430

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this prospective cohort study of Bangladeshi children, greater fecal immunoglobulin A, but not plasma immunoglobulin G, directed against the Cryptosporidium sporozoite-expressed antigen Cp23 at 12 months of age was associated with delayed time to subsequent cryptosporidiosis. This finding suggests a protective role for mucosal antibody-mediated immunity in naturally exposed children.

引用

页码：323 / 326

页数：4

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