Not "molecular patterns" but molecules

被引:22
作者
Beutler, B [1 ]
机构
[1] Scripps Res Inst, Dept Immunol, IMM 31, La Jolla, CA 92037 USA
关键词
D O I
10.1016/S1074-7613(03)00212-7
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In this issue of Immunity, Weber et al. show that LBP is multifunctional: able to sense not only LPS but peptidoglycan as well. The study helps to demystify the physical interactions that occur between host sensors and microbial inducers, and hints at one mechanism by which a limited number of receptors may engage a larger number of target molecules.
引用
收藏
页码:155 / 156
页数:2
相关论文
共 13 条
  • [1] Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition
    Akashi, S
    Nagai, Y
    Ogata, H
    Oikawa, M
    Fukase, K
    Kusumoto, S
    Kawasaki, K
    Nishijima, M
    Hayashi, S
    Kimoto, M
    Miyake, K
    [J]. INTERNATIONAL IMMUNOLOGY, 2001, 13 (12) : 1595 - 1599
  • [2] Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
    Alexopoulou, L
    Holt, AC
    Medzhitov, R
    Flavell, RA
    [J]. NATURE, 2001, 413 (6857) : 732 - 738
  • [3] Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex - Transfer from CD14 to TLR4 and MD-2
    Correia, JD
    Soldau, K
    Christen, U
    Tobias, PS
    Ulevitch, RJ
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (24) : 21129 - 21135
  • [4] The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein
    Gottar, M
    Gobert, V
    Michel, T
    Belvin, M
    Duyk, G
    Hoffmann, JA
    Ferrandon, D
    Royet, J
    [J]. NATURE, 2002, 416 (6881) : 640 - 644
  • [5] A Toll-like receptor recognizes bacterial DNA
    Hemmi, H
    Takeuchi, O
    Kawai, T
    Kaisho, T
    Sato, S
    Sanjo, H
    Matsumoto, M
    Hoshino, K
    Wagner, H
    Takeda, K
    Akira, S
    [J]. NATURE, 2000, 408 (6813) : 740 - 745
  • [6] JANEWAY CA, 1989, COLD SH Q B, V54, P1
  • [7] Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
    Lien, E
    Means, TK
    Heine, H
    Yoshimura, A
    Kusumoto, S
    Fukase, K
    Fenton, MJ
    Oikawa, M
    Qureshi, N
    Monks, B
    Finberg, RW
    Ingalls, RR
    Golenbock, DT
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (04) : 497 - 504
  • [8] Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation
    Poltorak, A
    Ricciardi-Castagnoli, P
    Citterio, S
    Beutler, B
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (05) : 2163 - 2167
  • [9] Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice:: Mutations in Tlr4 gene
    Poltorak, A
    He, XL
    Smirnova, I
    Liu, MY
    Van Huffel, C
    Du, X
    Birdwell, D
    Alejos, E
    Silva, M
    Galanos, C
    Freudenberg, M
    Ricciardi-Castagnoli, P
    Layton, B
    Beutler, B
    [J]. SCIENCE, 1998, 282 (5396) : 2085 - 2088
  • [10] STRUCTURE AND FUNCTION OF LIPOPOLYSACCHARIDE BINDING-PROTEIN
    SCHUMANN, RR
    LEONG, SR
    FLAGGS, GW
    GRAY, PW
    WRIGHT, SD
    MATHISON, JC
    TOBIAS, PS
    ULEVITCH, RJ
    [J]. SCIENCE, 1990, 249 (4975) : 1429 - 1431