Targeted Delivery of Bleomycin: A Comprehensive Anticancer Review

被引：53
作者：
Yu, Zhiqiang [1 ]
Yan, Bo [2 ]
Gao, Liqian [3 ]
Dong, Chenbo [4 ]
Zhong, Jian [5 ]
D'Ortenzio, Mathew [6 ]
Nguyen, Brandon [6 ]
Lee, Su Seong [3 ]
Hu, Xianglong [7 ,8 ]
Liang, Feng [9 ]
机构：
[1] Southern Med Univ, Guangdong Prov Key Lab New Drug Screening, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China
[2] Boston Univ, Sch Med, 670 Albany St,RM 504, Boston, MA 02118 USA
[3] Inst Bioengn & Nanotechnol, 31 Biopolis Way, Nanos 138669, Singapore
[4] W Virginia Univ, Dept Chem Engn, Morgantown, WV 26505 USA
[5] Natl Engn Res Ctr Nanotechnol, Shanghai 200241, Peoples R China
[6] Univ Waterloo, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada
[7] S China Normal Univ, Coll Bophoton, Key Lab Laser Life Sci, Minist Educ, Guangzhou 510631, Guangdong, Peoples R China
[8] S China Normal Univ, Coll Bophoton, Inst Laser Life Sci, Guangzhou 510631, Guangdong, Peoples R China
[9] Wuhan Univ Sci & Technol, State Key Lab Refractories & Met, Wuhan 430081, Peoples R China
来源：
CURRENT CANCER DRUG TARGETS | 2016年 / 16卷 / 06期
关键词：
Bleomycin; electrochemotherapy; liposomes; microsphere; nanoparticles; photochemical internalization; targeted drug delivery; ultrasound; STANDARD OPERATING PROCEDURES; MEDIATED DRUG-DELIVERY; OF-THE-ART; IN-VITRO; PHOTOCHEMICAL INTERNALIZATION; CELLULAR UPTAKE; CANCER-CELLS; POLYPRODRUG AMPHIPHILES; DISACCHARIDE MOIETY; GOLD NANOPARTICLES;
D O I：
10.2174/1568009616666151130213910
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Despite being one of the most effective broad-spectrum chemotherapeutic agents in the treatment of cancers, the clinical applications of bleomycins (BLMs) have been limited due to their poor drug delivery abilities, and the side effect of causing lung fibrosis. With the increased therapeutics and the reduction of side effects, research and development of targeted drug delivery systems (TDDS) with BLMs have become essential for the expansive clinical usage of BLM-based therapeutics. This review summarizes the recent developments of various TDDS for BLMs, including techniques such as photochemical internalization, ultrasound, and micelle, liposome, and nanoparticle formation. The advantages and disadvantages for each delivery approach are outlined, along with the specific challenges associated with each delivery system.
引用
收藏
页码：509 / 521
页数：13
相关论文
共 161 条
[1]   In vitro methods for evaluating therapeutic ultrasound exposures: present-day models and future innovations [J].
Alassaf, Ahmad ;
Aleid, Adham ;
Frenkel, Victor .
JOURNAL OF THERAPEUTIC ULTRASOUND, 2013, 1
[2]   Anti-CD19-targeted liposomal doxorubicin improves the therapeutic efficacy in murine B-cell lymphoma and ameliorates the toxicity of liposomes with varying drug release rates [J].
Allen, TM ;
Mumbengegwi, DR ;
Charrois, GJR .
CLINICAL CANCER RESEARCH, 2005, 11 (09) :3567-3573
[3]   Antibody-drug conjugates: targeted drug delivery for cancer [J].
Alley, Stephen C. ;
Okeley, Nicole M. ;
Senter, Peter D. .
CURRENT OPINION IN CHEMICAL BIOLOGY, 2010, 14 (04) :529-537
[4]   Liposomes for Enhanced Cytotoxic Activity of Bleomycin [J].
Alomrani, Abdullah H. ;
El Maghraby, Gamal M. ;
Alanazi, Fars K. ;
Al-Mohanna, Mai A. ;
Alaiya, Ayodele A. ;
Alsarra, Ibrahim A. .
DRUG DEVELOPMENT RESEARCH, 2011, 72 (03) :265-273
[5]   The effect of photochemical internalization of bleomycin in the treatment of urothelial carcinoma of the bladder: An in vitro study [J].
Arentsen, Harm C. ;
Falke, Johannes ;
Hogset, Anders ;
Oosterwijk, Egben ;
Witjes, J. Alfred .
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 2014, 32 (01) :49.e1-49.e6
[6]  
Arndt D, 2001, DRUG DELIV, V8, P1
[7]   A novel probe for the non-invasive detection of tumor-associated inflammation [J].
Balducci, Anthony ;
Wen, Yi ;
Zhang, Yang ;
Helfer, Brooke M. ;
Hitchens, T. Kevin ;
Meng, Wilson S. ;
Wesa, Amy K. ;
Janjic, Jelena M. .
ONCOIMMUNOLOGY, 2013, 2 (02)
[8]   Pharmacological studies of cisplatin encapsulated in long-circulating liposomes in mouse tumor models [J].
Bandak, S ;
Goren, D ;
Horowitz, A ;
Tzemach, D ;
Gabizon, A .
ANTI-CANCER DRUGS, 1999, 10 (10) :911-920
[9]   CELLULAR UPTAKE AND RELATIVE EFFICIENCY IN CELL INACTIVATION BY PHOTOACTIVATED SULFONATED MESO-TETRAPHENYLPORPHINES [J].
BERG, K ;
BOMMER, JC ;
WINKELMAN, JW ;
MOAN, J .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1990, 52 (04) :775-781
[10]   Site-specific drug delivery by photochemical internalization enhances the antitumor effect of bleomycin [J].
Berg, K ;
Dietze, A ;
Kaalhus, O ;
Hogset, A .
CLINICAL CANCER RESEARCH, 2005, 11 (23) :8476-8485
12345678910