Psychological resilience and the gene regulatory impact of posttraumatic stress in Nepali child soldiers

被引：64

作者：

Kohrt, Brandon A. ^{[1
,2
,3
]}

Worthman, Carol M. ^{[4
]}

Adhikari, Ramesh P. ^{[3
]}

Luitel, Nagendra P. ^{[3
]}

Arevalo, Jesusa M. G. ^{[5
,6
]}

Ma, Jeffrey ^{[5
,6
]}

McCreath, Heather ^{[7
]}

Seeman, Teresa E. ^{[7
,8
]}

Crimmins, Eileen M. ^{[9
]}

Cole, Steven W. ^{[5
,6
]}

机构：

[1] Duke Univ, Sch Med, Dept Psychiat & Behav Sci, Durham, NC 27708 USA

[2] Duke Univ, Duke Global Hlth Inst, Durham, NC 27710 USA

[3] Transcultural Psychosocial Org Nepal, Kathmandu 44616, Nepal

[4] Emory Univ, Dept Anthropol, Atlanta, GA 30322 USA

[5] Univ Calif Los Angeles, Sch Med, Dept Med, Div Hematol Oncol, Los Angeles, CA 90095 USA

[6] Univ Calif Los Angeles, Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA

[7] Univ Calif Los Angeles, Sch Med, Dept Med, Div Geriatr, Los Angeles, CA 90095 USA

[8] Univ Calif Los Angeles, Sch Med, Dept Epidemiol, Los Angeles, CA 90095 USA

[9] Univ So Calif, David Sch Gerontol, Los Angeles, CA 90089 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2016年 / 113卷 / 29期

基金：

美国国家卫生研究院;

关键词：

biocultural anthropology; child abuse; global mental health; low-income countries; social genomics; PTSD SYMPTOM SCALE; MENTAL-HEALTH; BLOOD SPOTS; LEUKOCYTE TRANSCRIPTOME; SOCIAL ECOLOGY; NEONATAL BLOOD; IMMUNE-SYSTEM; DRIED BLOOD; EXPRESSION; DEPRESSION;

D O I：

10.1073/pnas.1601301113

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Adverse social conditions in early life have been linked to increased expression of proinflammatory genes and reduced expression of antiviral genes in circulating immune cells-the conserved transcriptional response to adversity (CTRA). However, it remains unclear whether such effects are specific to the Western, educated, industrialized, rich, and democratic (WEIRD) cultural environments in which previous research has been conducted. To assess the roles of early adversity and individual psychological resilience in immune system gene regulation within a non-WEIRD population, we evaluated CTRA gene-expression profiles in 254 former child soldiers and matched noncombatant civilians 5 y after the People's War in Nepal. CTRA gene expression was up-regulated in former child soldiers. These effects were linked to the degree of experienced trauma and associated distress-that is, posttraumatic stress disorder (PTSD) severity-more than to child soldier status per se. Self-perceived psychological resilience was associated with marked buffering of CTRA activation such that PTSD-affected former child soldiers with high levels of personal resilience showed molecular profiles comparable to those of PTSD-free civilians. These results suggest that CTRA responses to early life adversity are not restricted to WEIRD cultural contexts and they underscore the key role of resilience in determining the molecular impact of adverse environments.

引用

页码：8156 / 8161

页数：6

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